TLR4 inhibits mesenchymal stem cell (MSC) STAT3 activation and thereby exerts deleterious effects on MSC-mediated cardioprotection

Bone marrow-derived mesenchymal stem cells (MSC) improve myocardial recovery after ischemia/reperfusion (I/R) injury. These effects are mediated in part by the paracrine secretion of angiogenic and tissue growth-promoting factors. Toll-like receptor 4 (TLR4) is expressed by MSC and induces apoptosis...

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Veröffentlicht in:	PloS one 2010-12, Vol.5 (12), p.e14206-e14206
Hauptverfasser:	Wang, Yue, Abarbanell, Aaron M, Herrmann, Jeremy L, Weil, Brent R, Manukyan, Mariuxi C, Poynter, Jeffrey A, Meldrum, Daniel R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes AKT protein Analysis Angiogenesis Animals Apoptosis Bone marrow Cardiotonic Agents - metabolism Cardiovascular Disorders/Coronary Artery Disease Cell activation Cell Biology/Cell Signaling Cell culture Cell growth Cell Proliferation Chemokines Cytokines Enzyme-linked immunosorbent assay Flow cytometry Heart Hyaluronan Receptors - biosynthesis Injuries Ischemia Kinases Male Medicine Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchyme Mice Mice, Inbred C57BL Mice, Knockout Myocardium - metabolism Neural stem cells Paracrine signalling Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Rats Rats, Sprague-Dawley Recovery Reperfusion Reperfusion Injury - pathology Rodents siRNA Stat3 protein STAT3 Transcription Factor - metabolism Stem cell transplantation Stem cells Surgery Surgery/Cardiothoracic Surgery TLR4 protein Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Toll-like receptors Transcription factors Vascular endothelial growth factor
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