O-glycosylation regulates ubiquitination and degradation of the anti-inflammatory protein A20 to accelerate atherosclerosis in diabetic ApoE-null mice

Accelerated atherosclerosis is the leading cause of morbidity and mortality in diabetic patients. Hyperglycemia is a recognized independent risk factor for heightened atherogenesis in diabetes mellitus (DM). However, our understanding of the mechanisms underlying glucose damage to the vasculature re...

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Veröffentlicht in:	PloS one 2010-12, Vol.5 (12), p.e14240-e14240
Hauptverfasser:	Shrikhande, Gautam V, Scali, Salvatore T, da Silva, Cleide G, Damrauer, Scott M, Csizmadia, Eva, Putheti, Prabhakar, Matthey, Michaela, Arjoon, Roy, Patel, Rakesh, Siracuse, Jeffrey J, Maccariello, Elizabeth R, Andersen, Nicholas D, Monahan, Thomas, Peterson, Clayton, Essayagh, Sanah, Studer, Peter, Guedes, Renata Padilha, Kocher, Olivier, Usheva, Anny, Veves, Aristidis, Kaczmarek, Elzbieta, Ferran, Christiane
Format:	Artikel
Sprache:	eng
Schlagworte:	A20 protein Acetylation Advanced glycosylation end products Animals Anti-inflammatory agents Aorta Aortic arch Apolipoprotein E Apolipoproteins Apolipoproteins E - genetics Arteriosclerosis Atherogenesis Atherosclerosis Atherosclerosis - metabolism Biology Blood vessels Cardiovascular disease Cardiovascular Disorders/Vascular Biology Coronary vessels Cosmetics industry Cysteine Endopeptidases - genetics Cysteine Endopeptidases - metabolism Degradation Diabetes Diabetes and Endocrinology/Type 1 Diabetes Diabetes and Endocrinology/Type 2 Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - metabolism Gene expression Gene transfer Glucosamine Glucose Glycosylation Grafts Health aspects Health risks Heart surgery House mouse Hyperglycemia Inflammation Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Kinases Lipopolysaccharides Lipopolysaccharides - metabolism Male Medical schools Medicine Mice Mice, Inbred C57BL Mice, Transgenic Mitogens Morbidity Mortality Myocytes, Smooth Muscle - cytology NF-kappa B - metabolism NF-κB protein O-GlcNAcylation Pathogenesis Pathology/Surgical Pathology Patients Phosphorylation Physicians Polypeptides Post-translation Proteasomes Protein kinase C Proteins Receptor for Advanced Glycation End Products Receptors, Immunologic - metabolism Risk factors RNA Rodents Smooth muscle Transcription Tumor necrosis factor Tumor Necrosis Factor alpha-Induced Protein 3 Tumor necrosis factor-TNF Ubiquitin Ubiquitin - chemistry Vascular surgery
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