Inhibition of the nuclear import of cubitus interruptus by roadkill in the presence of strong hedgehog signal
Hedgehog (Hh) signalling plays an important role in various developmental processes by activating the Cubitus interruptus (Ci)/Glioblastoma (Gli) family of transcription factors. In the process of proper pattern formation, Ci activity is regulated by multiple mechanisms, including processing, traffi...
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| creator | Seong, Ki-Hyeon Akimaru, Hiroshi Dai, Ping Nomura, Teruaki Okada, Masahiro Ishii, Shunsuke |
| description | Hedgehog (Hh) signalling plays an important role in various developmental processes by activating the Cubitus interruptus (Ci)/Glioblastoma (Gli) family of transcription factors. In the process of proper pattern formation, Ci activity is regulated by multiple mechanisms, including processing, trafficking, and degradation. However, it remains elusive how Ci distinctly recognizes the strong and moderate Hh signals. Roadkill (Rdx) induces Ci degradation in the anterior region of the Drosophila wing disc. Here, we report that Rdx inhibited Ci activity by two different mechanisms. In the region abutting the anterior/posterior boundary, which receives strong Hh signal, Rdx inhibited the nuclear import of Ci by releasing importin α3 from Ci. In this region, Rdx negatively regulated the expression of transcription factor Knot/Collier. In farther anterior regions receiving moderate levels of Hh signal, Rdx induced Ci degradation, as reported previously. Thus, two different mechanisms by which Rdx negatively regulates Ci may play an important role in the fine-tuning of Hh responses. |
| doi_str_mv | 10.1371/journal.pone.0015365 |
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In the process of proper pattern formation, Ci activity is regulated by multiple mechanisms, including processing, trafficking, and degradation. However, it remains elusive how Ci distinctly recognizes the strong and moderate Hh signals. Roadkill (Rdx) induces Ci degradation in the anterior region of the Drosophila wing disc. Here, we report that Rdx inhibited Ci activity by two different mechanisms. In the region abutting the anterior/posterior boundary, which receives strong Hh signal, Rdx inhibited the nuclear import of Ci by releasing importin α3 from Ci. In this region, Rdx negatively regulated the expression of transcription factor Knot/Collier. In farther anterior regions receiving moderate levels of Hh signal, Rdx induced Ci degradation, as reported previously. Thus, two different mechanisms by which Rdx negatively regulates Ci may play an important role in the fine-tuning of Hh responses.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0015365</identifier><identifier>PMID: 21179535</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Active Transport, Cell Nucleus ; Animals ; Biology ; Crosses, Genetic ; Degradation ; DNA-Binding Proteins - metabolism ; Drosophila ; Drosophila melanogaster ; Drosophila Proteins - metabolism ; Gene expression ; Genetics ; Genotype ; Glioblastoma ; Hedgehog protein ; Hedgehog Proteins - metabolism ; Hydrogels ; Imports ; Insects ; Intracellular Signaling Peptides and Proteins - metabolism ; Kinases ; Laboratories ; Models, Genetic ; Mutation ; Nuclear transport ; Pattern formation ; Plasmids - metabolism ; Protein Isoforms ; Proteins ; RDX ; Recovery (Medical) ; RNA Interference ; Signal processing ; Signal transduction ; Signaling ; Transcription factors ; Transcription Factors - metabolism ; Two-Hybrid System Techniques</subject><ispartof>PloS one, 2010-12, Vol.5 (12), p.e15365-e15365</ispartof><rights>COPYRIGHT 2010 Public Library of Science</rights><rights>2010 Seong et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Seong et al. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c757t-a8feacb000c4e4e0f3c34ebe590ff5875e2ecf6db9d1afe1b2aa11cdefcd79453</citedby><cites>FETCH-LOGICAL-c757t-a8feacb000c4e4e0f3c34ebe590ff5875e2ecf6db9d1afe1b2aa11cdefcd79453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002282/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002282/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21179535$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bergmann, Andreas</contributor><creatorcontrib>Seong, Ki-Hyeon</creatorcontrib><creatorcontrib>Akimaru, Hiroshi</creatorcontrib><creatorcontrib>Dai, Ping</creatorcontrib><creatorcontrib>Nomura, Teruaki</creatorcontrib><creatorcontrib>Okada, Masahiro</creatorcontrib><creatorcontrib>Ishii, Shunsuke</creatorcontrib><title>Inhibition of the nuclear import of cubitus interruptus by roadkill in the presence of strong hedgehog signal</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Hedgehog (Hh) signalling plays an important role in various developmental processes by activating the Cubitus interruptus (Ci)/Glioblastoma (Gli) family of transcription factors. In the process of proper pattern formation, Ci activity is regulated by multiple mechanisms, including processing, trafficking, and degradation. However, it remains elusive how Ci distinctly recognizes the strong and moderate Hh signals. Roadkill (Rdx) induces Ci degradation in the anterior region of the Drosophila wing disc. Here, we report that Rdx inhibited Ci activity by two different mechanisms. In the region abutting the anterior/posterior boundary, which receives strong Hh signal, Rdx inhibited the nuclear import of Ci by releasing importin α3 from Ci. In this region, Rdx negatively regulated the expression of transcription factor Knot/Collier. In farther anterior regions receiving moderate levels of Hh signal, Rdx induced Ci degradation, as reported previously. Thus, two different mechanisms by which Rdx negatively regulates Ci may play an important role in the fine-tuning of Hh responses.</description><subject>Active Transport, Cell Nucleus</subject><subject>Animals</subject><subject>Biology</subject><subject>Crosses, Genetic</subject><subject>Degradation</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Drosophila</subject><subject>Drosophila melanogaster</subject><subject>Drosophila Proteins - metabolism</subject><subject>Gene expression</subject><subject>Genetics</subject><subject>Genotype</subject><subject>Glioblastoma</subject><subject>Hedgehog protein</subject><subject>Hedgehog Proteins - metabolism</subject><subject>Hydrogels</subject><subject>Imports</subject><subject>Insects</subject><subject>Intracellular Signaling Peptides and Proteins - metabolism</subject><subject>Kinases</subject><subject>Laboratories</subject><subject>Models, Genetic</subject><subject>Mutation</subject><subject>Nuclear transport</subject><subject>Pattern formation</subject><subject>Plasmids - metabolism</subject><subject>Protein Isoforms</subject><subject>Proteins</subject><subject>RDX</subject><subject>Recovery (Medical)</subject><subject>RNA Interference</subject><subject>Signal processing</subject><subject>Signal transduction</subject><subject>Signaling</subject><subject>Transcription factors</subject><subject>Transcription Factors - metabolism</subject><subject>Two-Hybrid System Techniques</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7rr6D0QLguLFjEnTtM2NsCx-DCws-HUb0vSkzdgmNUnF_femO91lKnshvWg4fd43p29ykuQ5RltMSvxubydnRL8drYEtQpiSgj5ITjEj2abIEHl4tD5Jnni_R4iSqigeJycZxiWjhJ4mw850utZBW5NalYYOUjPJHoRL9TBaF-aqnCIx-VSbAM5N47yur1NnRfNT932s3whHBx6MhFnig7OmTTtoWuhsm3rdxmafJo-U6D08W95nyfePH75dfN5cXn3aXZxfbmRJy7ARlQIha4SQzCEHpIgkOdRAGVKKViWFDKQqmpo1WCjAdSYExrIBJZuS5ZScJS8PvmNvPV-S8hwTXDESQ8kisTsQjRV7Pjo9CHfNrdD8pmBdy4ULOibBCdSKsbwqRQV5TikTrJA5ApJRBYqo6PV-2W2qB2gkmOBEvzJdfzG64639zQlCWVbNzbxZDJz9NYEPfNBeQt8LA3byvIrnxYqyIpF89Q95_88tVCti_9ooG7eVsyc_z0tS4aJgZaS291DxaWDQMt4qpWN9JXi7EkQmwJ_Qisl7vvv65f_Zqx9r9vUR24HoQ-dtP82X0q_B_ABKZ713oO4yxojPQ3GbBp-Hgi9DEWUvjs_nTnQ7BeQvfAIKRQ</recordid><startdate>20101215</startdate><enddate>20101215</enddate><creator>Seong, Ki-Hyeon</creator><creator>Akimaru, Hiroshi</creator><creator>Dai, Ping</creator><creator>Nomura, Teruaki</creator><creator>Okada, Masahiro</creator><creator>Ishii, Shunsuke</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20101215</creationdate><title>Inhibition of the nuclear import of cubitus interruptus by roadkill in the presence of strong hedgehog signal</title><author>Seong, Ki-Hyeon ; Akimaru, Hiroshi ; Dai, Ping ; Nomura, Teruaki ; Okada, Masahiro ; Ishii, Shunsuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c757t-a8feacb000c4e4e0f3c34ebe590ff5875e2ecf6db9d1afe1b2aa11cdefcd79453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Active Transport, Cell Nucleus</topic><topic>Animals</topic><topic>Biology</topic><topic>Crosses, Genetic</topic><topic>Degradation</topic><topic>DNA-Binding Proteins - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seong, Ki-Hyeon</au><au>Akimaru, Hiroshi</au><au>Dai, Ping</au><au>Nomura, Teruaki</au><au>Okada, Masahiro</au><au>Ishii, Shunsuke</au><au>Bergmann, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of the nuclear import of cubitus interruptus by roadkill in the presence of strong hedgehog signal</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2010-12-15</date><risdate>2010</risdate><volume>5</volume><issue>12</issue><spage>e15365</spage><epage>e15365</epage><pages>e15365-e15365</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Hedgehog (Hh) signalling plays an important role in various developmental processes by activating the Cubitus interruptus (Ci)/Glioblastoma (Gli) family of transcription factors. In the process of proper pattern formation, Ci activity is regulated by multiple mechanisms, including processing, trafficking, and degradation. However, it remains elusive how Ci distinctly recognizes the strong and moderate Hh signals. Roadkill (Rdx) induces Ci degradation in the anterior region of the Drosophila wing disc. Here, we report that Rdx inhibited Ci activity by two different mechanisms. In the region abutting the anterior/posterior boundary, which receives strong Hh signal, Rdx inhibited the nuclear import of Ci by releasing importin α3 from Ci. In this region, Rdx negatively regulated the expression of transcription factor Knot/Collier. In farther anterior regions receiving moderate levels of Hh signal, Rdx induced Ci degradation, as reported previously. Thus, two different mechanisms by which Rdx negatively regulates Ci may play an important role in the fine-tuning of Hh responses.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>21179535</pmid><doi>10.1371/journal.pone.0015365</doi><tpages>e15365</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Active Transport, Cell Nucleus Animals Biology Crosses, Genetic Degradation DNA-Binding Proteins - metabolism Drosophila Drosophila melanogaster Drosophila Proteins - metabolism Gene expression Genetics Genotype Glioblastoma Hedgehog protein Hedgehog Proteins - metabolism Hydrogels Imports Insects Intracellular Signaling Peptides and Proteins - metabolism Kinases Laboratories Models, Genetic Mutation Nuclear transport Pattern formation Plasmids - metabolism Protein Isoforms Proteins RDX Recovery (Medical) RNA Interference Signal processing Signal transduction Signaling Transcription factors Transcription Factors - metabolism Two-Hybrid System Techniques |
| title | Inhibition of the nuclear import of cubitus interruptus by roadkill in the presence of strong hedgehog signal |
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