Cystatin C: a candidate biomarker for amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal neurologic disease characterized by progressive motor neuron degeneration. Clinical disease management is hindered by both a lengthy diagnostic process and the absence of effective treatments. Reliable panels of diagnostic, surrogate, and prognostic bio...

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Veröffentlicht in:	PloS one 2010-12, Vol.5 (12), p.e15133-e15133
Hauptverfasser:	Wilson, Meghan E, Boumaza, Imene, Lacomis, David, Bowser, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - blood Amyotrophic Lateral Sclerosis - mortality Apoptosis Bioindicators Biology Biomarkers Cerebrospinal fluid Clinical trials Cystatin C Cystatin C - blood Cysteine Cysteine proteinase Degeneration Development and progression Diagnostic systems Disease control Disease Progression Drug development Drug therapy Enzyme-linked immunosorbent assay Enzyme-Linked Immunosorbent Assay - methods Female Generalized linear models Humans Male Mass spectrometry Mass Spectrometry - methods Medical diagnosis Medical prognosis Medicine Middle Aged Multiple sclerosis Nervous system diseases Neurons Oxidative stress Pathology Patients Plasma Prognosis Protease inhibitors Proteases Proteins Proteomics Proteomics - methods Regression Analysis Scientific imaging Studies Survival Treatment Outcome
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