An inducer of VGF protects cells against ER stress-induced cell death and prolongs survival in the mutant SOD1 animal models of familial ALS

Amyotrophic lateral sclerosis (ALS) is the most frequent adult-onset motor neuron disease, and recent evidence has suggested that endoplasmic reticulum (ER) stress signaling is involved in the pathogenesis of ALS. Here we identified a small molecule, SUN N8075, which has a marked protective effect o...

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Veröffentlicht in:	PloS one 2010-12, Vol.5 (12), p.e15307-e15307
Hauptverfasser:	Shimazawa, Masamitsu, Tanaka, Hirotaka, Ito, Yasushi, Morimoto, Nobutaka, Tsuruma, Kazuhiro, Kadokura, Michinori, Tamura, Shigeki, Inoue, Teruyoshi, Yamada, Mitsunori, Takahashi, Hitoshi, Warita, Hitoshi, Aoki, Masashi, Hara, Hideaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - genetics Aniline Compounds - pharmacology Animal models Animals Apoptosis Biochemistry Biology Biomarkers Biomedical research Brain research Cell Death Cell Survival Cords Dementia Disease control Disease Models, Animal Disease Progression Endoplasmic reticulum Endoplasmic Reticulum - metabolism Genetic aspects Genetic engineering Growth factors Humans Laboratories Medicine Mice Mice, Transgenic Microscopy Mortality Motor neuron diseases Mutation Nerve growth factor Neurology Neurons Neuropeptides Oligonucleotide Array Sequence Analysis Pathogenesis Patients Peptides Pharmaceuticals Pharmacology Piperazines - pharmacology Potassium Proteins Rodents Signaling siRNA Stress Stresses Sun Superoxide dismutase Superoxide Dismutase - genetics Superoxide Dismutase-1 Survival Transgenic mice Vascular Endothelial Growth Factor A - metabolism
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