Kita driven expression of oncogenic HRAS leads to early onset and highly penetrant melanoma in zebrafish

Melanoma is the most aggressive and lethal form of skin cancer. Because of the increasing incidence and high lethality of melanoma, animal models for continuously observing melanoma formation and progression as well as for testing pharmacological agents are needed. Using the combinatorial Gal4-UAS s...

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Veröffentlicht in:	PloS one 2010-12, Vol.5 (12), p.e15170-e15170
Hauptverfasser:	Santoriello, Cristina, Gennaro, Elisa, Anelli, Viviana, Distel, Martin, Kelly, Amanda, Köster, Reinhard W, Hurlstone, Adam, Mione, Marina
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal genetic engineering Animal models Animals Animals, Genetically Modified Biology Cancer Combinatorial analysis Danio rerio Disease Models, Animal Disease Progression Freshwater Gene Expression Regulation, Neoplastic Genes, p53 Genetic screening Genetically modified animals Immunology Laboratories Larvae Lethality Life sciences Ligands Lubricants Medicine Melanocytes Melanocytes - cytology Melanocytes - metabolism Melanoma Melanoma - genetics Melanoma - metabolism Metastasis Models, Genetic Mutation Oncology Pharmacology Phenotype Pigmentation Promoter Regions, Genetic Proto-Oncogene Proteins c-kit - metabolism Proto-Oncogene Proteins p21(ras) - metabolism PTEN Phosphohydrolase - metabolism Screens Senescence Skin Skin cancer Skin diseases Skin Neoplasms - genetics Skin Neoplasms - metabolism Stem cells Suppressors Transgenes Transgenic fish Tumors Zebrafish
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