The neurotoxicity of DOPAL: behavioral and stereological evidence for its role in Parkinson disease pathogenesis

The etiology of Parkinson disease (PD) has yet to be fully elucidated. We examined the consequences of injections of 3,4-dihydroxyphenylacetaldehyde (DOPAL), a toxic metabolite of dopamine, into the substantia nigra of rats on motor behavior and neuronal survival. A total of 800 nl/rat of DOPAL (1 µ...

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Veröffentlicht in:	PloS one 2010-12, Vol.5 (12), p.e15251
Hauptverfasser:	Panneton, W Michael, Kumar, V B, Gan, Qi, Burke, William J, Galvin, James E
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dihydroxyphenylacetic Acid - analogs & derivatives 3,4-Dihydroxyphenylacetic Acid - pharmacology 3,4-Dihydroxyphenylacetic Acid - toxicity Analysis Animal behavior Animal models Animals Apoptosis Asymmetry Behavior Behavior, Animal Biocompatibility Biology Cell survival Development and progression Disruption Dopamine Dopamine - metabolism Dopamine receptors Drug dosages Etiology Glial Fibrillary Acidic Protein - metabolism Hydroxylase Hydroxylases Hypotheses Immunohistochemistry - methods In vivo methods and tests Laboratories Male Medicine Metabolism Metabolites Microglia - drug effects Movement disorders Neostriatum Neurodegenerative diseases Neuronal-glial interactions Neurons Neurons - drug effects Neurons - metabolism Neurotoxicity Optical density Parkinson disease Parkinson Disease - drug therapy Parkinson Disease - metabolism Parkinson's disease Parkinsons disease Pathogenesis Permeability Phenotype Phosphates Physiology Rats Rats, Sprague-Dawley Resveratrol Rodents Rotational behavior Substantia nigra Substantia Nigra - drug effects Transmitters Tyrosine Tyrosine 3-monooxygenase Tyrosine 3-Monooxygenase - metabolism
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