Does the KIR2DS5 gene protect from some human diseases?
KIR2DS5 gene encodes an activating natural killer cell receptor whose ligand is not known. It was recently reported to affect the outcome of hematopoietic stem cell transplantation. In our studies on KIR2DS5 gene associations with human diseases, we compared the frequencies of this gene in patients...
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| Veröffentlicht in: | PloS one 2010-08, Vol.5 (8), p.e12381-e12381 |
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| creator | Nowak, Izabela Majorczyk, Edyta Wiśniewski, Andrzej Pawlik, Andrzej Magott-Procelewska, Maria Passowicz-Muszyńska, Ewa Malejczyk, Jacek Płoski, Rafał Giebel, Sebastian Barcz, Ewa Zoń-Giebel, Aleksandra Malinowski, Andrzej Tchórzewski, Henryk Chlebicki, Arkadiusz Łuszczek, Wioleta Kurpisz, Maciej Gryboś, Marian Wilczyński, Jacek Wiland, Piotr Senitzer, David Sun, Ji-Yao Jankowska, Renata Klinger, Marian Kuśnierczyk, Piotr |
| description | KIR2DS5 gene encodes an activating natural killer cell receptor whose ligand is not known. It was recently reported to affect the outcome of hematopoietic stem cell transplantation.
In our studies on KIR2DS5 gene associations with human diseases, we compared the frequencies of this gene in patients and relevant controls. Typing for KIR2DS5 gene was performed by either individual or multiplex polymerase chain reactions which, when compared in the same samples, gave concordant results. We noted an apparently protective effect of KIR2DS5 gene presence in several clinical conditions, but not in others. Namely, this effect was observed in ankylosing spondylitis (p=0.003, odds ratio [OR]=0.47, confidence interval [CI]=0.28-0.79), endometriosis (p=0.03, OR=0.25, CI = 0.07-0.82) and acute rejection of kidney graft (p=0.0056, OR=0.44, CI=0.24-0.80), but not in non-small-cell lung carcinoma, rheumatoid arthritis, spontaneous abortion, or leukemia (all p>0.05). In addition, the simultaneous presence of KIR2DS5 gene and HLA-C C1 allotype exhibited an even stronger protective effect on ankylosing spondylitis (p=0.0003, OR=0.35, CI=0.19-0.65), whereas a lack of KIR2DS5 and the presence of the HLA-C C2 allotype was associated with ankylosing spondylitis (p=0.0017, OR=1.92, CI=1.28-2.89), whereas a lack of KIR2DS5 and presence of C1 allotype was associated with rheumatoid arthritis (p=0.005, OR=1.47, CI=1.13-1.92). The presence of both KIR2DS5 and C1 seemed to protect from acute kidney graft rejection (p=0.017, OR=0.47, CI=0.25-0.89), whereas lack of KIR2DS5 and presence of C2 seemed to favor rejection (p=0.0015, OR=2.13, CI=1.34-3.37).
Our results suggest that KIR2DS5 may protect from endometriosis, ankylosing spondylitis, and acute rejection of kidney graft. |
| doi_str_mv | 10.1371/journal.pone.0012381 |
| format | Article |
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In our studies on KIR2DS5 gene associations with human diseases, we compared the frequencies of this gene in patients and relevant controls. Typing for KIR2DS5 gene was performed by either individual or multiplex polymerase chain reactions which, when compared in the same samples, gave concordant results. We noted an apparently protective effect of KIR2DS5 gene presence in several clinical conditions, but not in others. Namely, this effect was observed in ankylosing spondylitis (p=0.003, odds ratio [OR]=0.47, confidence interval [CI]=0.28-0.79), endometriosis (p=0.03, OR=0.25, CI = 0.07-0.82) and acute rejection of kidney graft (p=0.0056, OR=0.44, CI=0.24-0.80), but not in non-small-cell lung carcinoma, rheumatoid arthritis, spontaneous abortion, or leukemia (all p>0.05). In addition, the simultaneous presence of KIR2DS5 gene and HLA-C C1 allotype exhibited an even stronger protective effect on ankylosing spondylitis (p=0.0003, OR=0.35, CI=0.19-0.65), whereas a lack of KIR2DS5 and the presence of the HLA-C C2 allotype was associated with ankylosing spondylitis (p=0.0017, OR=1.92, CI=1.28-2.89), whereas a lack of KIR2DS5 and presence of C1 allotype was associated with rheumatoid arthritis (p=0.005, OR=1.47, CI=1.13-1.92). The presence of both KIR2DS5 and C1 seemed to protect from acute kidney graft rejection (p=0.017, OR=0.47, CI=0.25-0.89), whereas lack of KIR2DS5 and presence of C2 seemed to favor rejection (p=0.0015, OR=2.13, CI=1.34-3.37).
Our results suggest that KIR2DS5 may protect from endometriosis, ankylosing spondylitis, and acute rejection of kidney graft.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0012381</identifier><identifier>PMID: 20865034</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abortion ; Adult ; Aged ; Aged, 80 and over ; Ankylosing spondylitis ; Arthritis ; Bone marrow ; Classification ; Comparative analysis ; Confidence intervals ; Disease - genetics ; Endometriosis ; Endometriosis - genetics ; Female ; Gene Frequency ; Genes ; Genetics and Genomics/Genetics of Disease ; Genetics and Genomics/Genetics of the Immune System ; Genetics and Genomics/Medical Genetics ; Genetics and Genomics/Population Genetics ; Graft rejection ; Graft Rejection - genetics ; Grafting ; Gynecology ; Hematopoietic stem cell transplantation ; Hematopoietic stem cells ; Histocompatibility antigen HLA ; HLA antigens ; Hospitals ; Humans ; Immunoglobulins ; Immunology ; Immunology/Autoimmunity ; Immunology/Genetics of the Immune System ; Immunology/Reproductive Immunology ; Kidney transplantation ; Killer cells ; KIR2DS5 gene ; Leukemia ; Ligands ; Lung cancer ; Lung carcinoma ; Male ; Medical research ; Medicine ; Middle Aged ; Miscarriage ; Multiplexing ; Natural killer cells ; Nephrology ; Non-small cell lung cancer ; Non-small cell lung carcinoma ; Obstetrics ; Polymerase chain reaction ; Potassium channels (inwardly-rectifying) ; Psoriasis ; Receptors, KIR - genetics ; Receptors, KIR - metabolism ; Rejection ; Reproductive health ; Rheumatoid arthritis ; Rheumatoid factor ; Rheumatology ; Spondylitis ; Spondylitis, Ankylosing - genetics ; Stem cell transplantation ; Stem cells ; Tissue typing ; Transplantation ; Transplants & implants ; Tumors ; Womens health ; Young Adult</subject><ispartof>PloS one, 2010-08, Vol.5 (8), p.e12381-e12381</ispartof><rights>COPYRIGHT 2010 Public Library of Science</rights><rights>2010 Nowak et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Nowak et al. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c789t-16e76dba294329876e318638f3e3900f722830123c04de48686438cac2112bbe3</citedby><cites>FETCH-LOGICAL-c789t-16e76dba294329876e318638f3e3900f722830123c04de48686438cac2112bbe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928722/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928722/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20865034$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Zimmer, Jacques</contributor><creatorcontrib>Nowak, Izabela</creatorcontrib><creatorcontrib>Majorczyk, Edyta</creatorcontrib><creatorcontrib>Wiśniewski, Andrzej</creatorcontrib><creatorcontrib>Pawlik, Andrzej</creatorcontrib><creatorcontrib>Magott-Procelewska, Maria</creatorcontrib><creatorcontrib>Passowicz-Muszyńska, Ewa</creatorcontrib><creatorcontrib>Malejczyk, Jacek</creatorcontrib><creatorcontrib>Płoski, Rafał</creatorcontrib><creatorcontrib>Giebel, Sebastian</creatorcontrib><creatorcontrib>Barcz, Ewa</creatorcontrib><creatorcontrib>Zoń-Giebel, Aleksandra</creatorcontrib><creatorcontrib>Malinowski, Andrzej</creatorcontrib><creatorcontrib>Tchórzewski, Henryk</creatorcontrib><creatorcontrib>Chlebicki, Arkadiusz</creatorcontrib><creatorcontrib>Łuszczek, Wioleta</creatorcontrib><creatorcontrib>Kurpisz, Maciej</creatorcontrib><creatorcontrib>Gryboś, Marian</creatorcontrib><creatorcontrib>Wilczyński, Jacek</creatorcontrib><creatorcontrib>Wiland, Piotr</creatorcontrib><creatorcontrib>Senitzer, David</creatorcontrib><creatorcontrib>Sun, Ji-Yao</creatorcontrib><creatorcontrib>Jankowska, Renata</creatorcontrib><creatorcontrib>Klinger, Marian</creatorcontrib><creatorcontrib>Kuśnierczyk, Piotr</creatorcontrib><title>Does the KIR2DS5 gene protect from some human diseases?</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>KIR2DS5 gene encodes an activating natural killer cell receptor whose ligand is not known. It was recently reported to affect the outcome of hematopoietic stem cell transplantation.
In our studies on KIR2DS5 gene associations with human diseases, we compared the frequencies of this gene in patients and relevant controls. Typing for KIR2DS5 gene was performed by either individual or multiplex polymerase chain reactions which, when compared in the same samples, gave concordant results. We noted an apparently protective effect of KIR2DS5 gene presence in several clinical conditions, but not in others. Namely, this effect was observed in ankylosing spondylitis (p=0.003, odds ratio [OR]=0.47, confidence interval [CI]=0.28-0.79), endometriosis (p=0.03, OR=0.25, CI = 0.07-0.82) and acute rejection of kidney graft (p=0.0056, OR=0.44, CI=0.24-0.80), but not in non-small-cell lung carcinoma, rheumatoid arthritis, spontaneous abortion, or leukemia (all p>0.05). In addition, the simultaneous presence of KIR2DS5 gene and HLA-C C1 allotype exhibited an even stronger protective effect on ankylosing spondylitis (p=0.0003, OR=0.35, CI=0.19-0.65), whereas a lack of KIR2DS5 and the presence of the HLA-C C2 allotype was associated with ankylosing spondylitis (p=0.0017, OR=1.92, CI=1.28-2.89), whereas a lack of KIR2DS5 and presence of C1 allotype was associated with rheumatoid arthritis (p=0.005, OR=1.47, CI=1.13-1.92). The presence of both KIR2DS5 and C1 seemed to protect from acute kidney graft rejection (p=0.017, OR=0.47, CI=0.25-0.89), whereas lack of KIR2DS5 and presence of C2 seemed to favor rejection (p=0.0015, OR=2.13, CI=1.34-3.37).
Our results suggest that KIR2DS5 may protect from endometriosis, ankylosing spondylitis, and acute rejection of kidney graft.</description><subject>Abortion</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Ankylosing spondylitis</subject><subject>Arthritis</subject><subject>Bone marrow</subject><subject>Classification</subject><subject>Comparative analysis</subject><subject>Confidence intervals</subject><subject>Disease - genetics</subject><subject>Endometriosis</subject><subject>Endometriosis - genetics</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genes</subject><subject>Genetics and Genomics/Genetics of Disease</subject><subject>Genetics and Genomics/Genetics of the Immune System</subject><subject>Genetics and Genomics/Medical Genetics</subject><subject>Genetics and Genomics/Population Genetics</subject><subject>Graft rejection</subject><subject>Graft Rejection - genetics</subject><subject>Grafting</subject><subject>Gynecology</subject><subject>Hematopoietic stem cell transplantation</subject><subject>Hematopoietic stem cells</subject><subject>Histocompatibility antigen HLA</subject><subject>HLA antigens</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Immunology</subject><subject>Immunology/Autoimmunity</subject><subject>Immunology/Genetics of the Immune System</subject><subject>Immunology/Reproductive Immunology</subject><subject>Kidney transplantation</subject><subject>Killer cells</subject><subject>KIR2DS5 gene</subject><subject>Leukemia</subject><subject>Ligands</subject><subject>Lung cancer</subject><subject>Lung carcinoma</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Miscarriage</subject><subject>Multiplexing</subject><subject>Natural killer cells</subject><subject>Nephrology</subject><subject>Non-small cell lung cancer</subject><subject>Non-small cell lung carcinoma</subject><subject>Obstetrics</subject><subject>Polymerase chain reaction</subject><subject>Potassium channels (inwardly-rectifying)</subject><subject>Psoriasis</subject><subject>Receptors, KIR - genetics</subject><subject>Receptors, KIR - metabolism</subject><subject>Rejection</subject><subject>Reproductive health</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatoid factor</subject><subject>Rheumatology</subject><subject>Spondylitis</subject><subject>Spondylitis, Ankylosing - genetics</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Tissue typing</subject><subject>Transplantation</subject><subject>Transplants & implants</subject><subject>Tumors</subject><subject>Womens health</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9tu1DAQhiMEogd4AwSRkEBc7OJD4sMNqGo5rKhUqQVuLceZZLNK4q3tVPD2ON202qBKIF_Ysr_5Z8YzkyQvMFpiyvH7jR1cr9vl1vawRAgTKvCj5BBLShaMIPp473yQHHm_QSingrGnyQFBguWIZocJP7Pg07CG9Nvqkpxd5WkNPaRbZwOYkFbOdqm3HaTrodN9WjYetAf_8VnypNKth-fTfpz8-Pzp--nXxfnFl9XpyfnCcCHDAjPgrCw0kRklUnAGFAtGRUWBSoQqToigY-wGZSVkggmWUWG0IRiTogB6nLza6W5b69WUs1c4ykjKCZKRWO2I0uqN2rqm0-63srpRtxfW1Uq70JgWFK-4yXipo9sqKzCWpijLImekMDEMk0etD5O3oeigNNAHp9uZ6Pylb9aqtjeKSCJiLlHg7STg7PUAPqiu8QbaVvdgB69knuWcIyz_SfI8x1wIMgb1-i_y4W-YqFrHTJu-sjFAM2qqk4xTwWl-Sy0foOIqoWtM7KSqifczg3czg8gE-BVqPXivVleX_89e_Jyzb_bYNeg2rL1th9DY3s_BbAcaZ713UN1XAyM1DsLdb6hxENQ0CNHs5X4l743uOp_-AcnU_uw</recordid><startdate>20100826</startdate><enddate>20100826</enddate><creator>Nowak, 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the KIR2DS5 gene protect from some human diseases?</title><author>Nowak, Izabela ; Majorczyk, Edyta ; Wiśniewski, Andrzej ; Pawlik, Andrzej ; Magott-Procelewska, Maria ; Passowicz-Muszyńska, Ewa ; Malejczyk, Jacek ; Płoski, Rafał ; Giebel, Sebastian ; Barcz, Ewa ; Zoń-Giebel, Aleksandra ; Malinowski, Andrzej ; Tchórzewski, Henryk ; Chlebicki, Arkadiusz ; Łuszczek, Wioleta ; Kurpisz, Maciej ; Gryboś, Marian ; Wilczyński, Jacek ; Wiland, Piotr ; Senitzer, David ; Sun, Ji-Yao ; Jankowska, Renata ; Klinger, Marian ; Kuśnierczyk, Piotr</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c789t-16e76dba294329876e318638f3e3900f722830123c04de48686438cac2112bbe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Abortion</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Ankylosing spondylitis</topic><topic>Arthritis</topic><topic>Bone marrow</topic><topic>Classification</topic><topic>Comparative analysis</topic><topic>Confidence intervals</topic><topic>Disease - genetics</topic><topic>Endometriosis</topic><topic>Endometriosis - genetics</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genes</topic><topic>Genetics and Genomics/Genetics of Disease</topic><topic>Genetics and Genomics/Genetics of the Immune System</topic><topic>Genetics and Genomics/Medical Genetics</topic><topic>Genetics and Genomics/Population Genetics</topic><topic>Graft rejection</topic><topic>Graft Rejection - genetics</topic><topic>Grafting</topic><topic>Gynecology</topic><topic>Hematopoietic stem cell transplantation</topic><topic>Hematopoietic stem cells</topic><topic>Histocompatibility antigen HLA</topic><topic>HLA antigens</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Immunology</topic><topic>Immunology/Autoimmunity</topic><topic>Immunology/Genetics of the Immune System</topic><topic>Immunology/Reproductive Immunology</topic><topic>Kidney transplantation</topic><topic>Killer cells</topic><topic>KIR2DS5 gene</topic><topic>Leukemia</topic><topic>Ligands</topic><topic>Lung cancer</topic><topic>Lung carcinoma</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Miscarriage</topic><topic>Multiplexing</topic><topic>Natural killer cells</topic><topic>Nephrology</topic><topic>Non-small cell lung cancer</topic><topic>Non-small cell lung carcinoma</topic><topic>Obstetrics</topic><topic>Polymerase chain reaction</topic><topic>Potassium channels (inwardly-rectifying)</topic><topic>Psoriasis</topic><topic>Receptors, KIR - genetics</topic><topic>Receptors, KIR - metabolism</topic><topic>Rejection</topic><topic>Reproductive health</topic><topic>Rheumatoid arthritis</topic><topic>Rheumatoid factor</topic><topic>Rheumatology</topic><topic>Spondylitis</topic><topic>Spondylitis, Ankylosing - genetics</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Tissue typing</topic><topic>Transplantation</topic><topic>Transplants & implants</topic><topic>Tumors</topic><topic>Womens health</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nowak, Izabela</creatorcontrib><creatorcontrib>Majorczyk, Edyta</creatorcontrib><creatorcontrib>Wiśniewski, Andrzej</creatorcontrib><creatorcontrib>Pawlik, Andrzej</creatorcontrib><creatorcontrib>Magott-Procelewska, Maria</creatorcontrib><creatorcontrib>Passowicz-Muszyńska, Ewa</creatorcontrib><creatorcontrib>Malejczyk, Jacek</creatorcontrib><creatorcontrib>Płoski, Rafał</creatorcontrib><creatorcontrib>Giebel, Sebastian</creatorcontrib><creatorcontrib>Barcz, Ewa</creatorcontrib><creatorcontrib>Zoń-Giebel, Aleksandra</creatorcontrib><creatorcontrib>Malinowski, Andrzej</creatorcontrib><creatorcontrib>Tchórzewski, Henryk</creatorcontrib><creatorcontrib>Chlebicki, Arkadiusz</creatorcontrib><creatorcontrib>Łuszczek, Wioleta</creatorcontrib><creatorcontrib>Kurpisz, Maciej</creatorcontrib><creatorcontrib>Gryboś, Marian</creatorcontrib><creatorcontrib>Wilczyński, Jacek</creatorcontrib><creatorcontrib>Wiland, Piotr</creatorcontrib><creatorcontrib>Senitzer, David</creatorcontrib><creatorcontrib>Sun, Ji-Yao</creatorcontrib><creatorcontrib>Jankowska, Renata</creatorcontrib><creatorcontrib>Klinger, Marian</creatorcontrib><creatorcontrib>Kuśnierczyk, Piotr</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints in Context (Gale)</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior 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Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials science collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nowak, Izabela</au><au>Majorczyk, Edyta</au><au>Wiśniewski, Andrzej</au><au>Pawlik, Andrzej</au><au>Magott-Procelewska, Maria</au><au>Passowicz-Muszyńska, Ewa</au><au>Malejczyk, Jacek</au><au>Płoski, Rafał</au><au>Giebel, Sebastian</au><au>Barcz, Ewa</au><au>Zoń-Giebel, Aleksandra</au><au>Malinowski, Andrzej</au><au>Tchórzewski, Henryk</au><au>Chlebicki, Arkadiusz</au><au>Łuszczek, Wioleta</au><au>Kurpisz, Maciej</au><au>Gryboś, Marian</au><au>Wilczyński, Jacek</au><au>Wiland, Piotr</au><au>Senitzer, David</au><au>Sun, Ji-Yao</au><au>Jankowska, Renata</au><au>Klinger, Marian</au><au>Kuśnierczyk, Piotr</au><au>Zimmer, Jacques</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does the KIR2DS5 gene protect from some human diseases?</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2010-08-26</date><risdate>2010</risdate><volume>5</volume><issue>8</issue><spage>e12381</spage><epage>e12381</epage><pages>e12381-e12381</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>KIR2DS5 gene encodes an activating natural killer cell receptor whose ligand is not known. It was recently reported to affect the outcome of hematopoietic stem cell transplantation.
In our studies on KIR2DS5 gene associations with human diseases, we compared the frequencies of this gene in patients and relevant controls. Typing for KIR2DS5 gene was performed by either individual or multiplex polymerase chain reactions which, when compared in the same samples, gave concordant results. We noted an apparently protective effect of KIR2DS5 gene presence in several clinical conditions, but not in others. Namely, this effect was observed in ankylosing spondylitis (p=0.003, odds ratio [OR]=0.47, confidence interval [CI]=0.28-0.79), endometriosis (p=0.03, OR=0.25, CI = 0.07-0.82) and acute rejection of kidney graft (p=0.0056, OR=0.44, CI=0.24-0.80), but not in non-small-cell lung carcinoma, rheumatoid arthritis, spontaneous abortion, or leukemia (all p>0.05). In addition, the simultaneous presence of KIR2DS5 gene and HLA-C C1 allotype exhibited an even stronger protective effect on ankylosing spondylitis (p=0.0003, OR=0.35, CI=0.19-0.65), whereas a lack of KIR2DS5 and the presence of the HLA-C C2 allotype was associated with ankylosing spondylitis (p=0.0017, OR=1.92, CI=1.28-2.89), whereas a lack of KIR2DS5 and presence of C1 allotype was associated with rheumatoid arthritis (p=0.005, OR=1.47, CI=1.13-1.92). The presence of both KIR2DS5 and C1 seemed to protect from acute kidney graft rejection (p=0.017, OR=0.47, CI=0.25-0.89), whereas lack of KIR2DS5 and presence of C2 seemed to favor rejection (p=0.0015, OR=2.13, CI=1.34-3.37).
Our results suggest that KIR2DS5 may protect from endometriosis, ankylosing spondylitis, and acute rejection of kidney graft.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>20865034</pmid><doi>10.1371/journal.pone.0012381</doi><tpages>e12381</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2010-08, Vol.5 (8), p.e12381-e12381 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1318937209 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; PubMed Central; Directory of Open Access Journals; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
| subjects | Abortion Adult Aged Aged, 80 and over Ankylosing spondylitis Arthritis Bone marrow Classification Comparative analysis Confidence intervals Disease - genetics Endometriosis Endometriosis - genetics Female Gene Frequency Genes Genetics and Genomics/Genetics of Disease Genetics and Genomics/Genetics of the Immune System Genetics and Genomics/Medical Genetics Genetics and Genomics/Population Genetics Graft rejection Graft Rejection - genetics Grafting Gynecology Hematopoietic stem cell transplantation Hematopoietic stem cells Histocompatibility antigen HLA HLA antigens Hospitals Humans Immunoglobulins Immunology Immunology/Autoimmunity Immunology/Genetics of the Immune System Immunology/Reproductive Immunology Kidney transplantation Killer cells KIR2DS5 gene Leukemia Ligands Lung cancer Lung carcinoma Male Medical research Medicine Middle Aged Miscarriage Multiplexing Natural killer cells Nephrology Non-small cell lung cancer Non-small cell lung carcinoma Obstetrics Polymerase chain reaction Potassium channels (inwardly-rectifying) Psoriasis Receptors, KIR - genetics Receptors, KIR - metabolism Rejection Reproductive health Rheumatoid arthritis Rheumatoid factor Rheumatology Spondylitis Spondylitis, Ankylosing - genetics Stem cell transplantation Stem cells Tissue typing Transplantation Transplants & implants Tumors Womens health Young Adult |
| title | Does the KIR2DS5 gene protect from some human diseases? |
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