Rhabdastrellic acid-A induced autophagy-associated cell death through blocking Akt pathway in human cancer cells

Autophagy is an evolutionarily conserved protein degradation pathway. A defect in autophagy may contribute to tumorigenesis. Autophagy inducers could have a potential function in tumor prevention and treatment. Our results showed that Rhabdastrellic acid-A, an isomalabaricane triterpenoid isolated f...

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Veröffentlicht in:	PloS one 2010-08, Vol.5 (8), p.e12176
Hauptverfasser:	Li, Dan-Dan, Guo, Jing-Feng, Huang, Jia-Jia, Wang, Lin-Lin, Deng, Rong, Liu, Jian-Nan, Feng, Gong-Kan, Xiao, Ding-Jun, Deng, Song-Zhi, Zhang, Xiao-Shi, Zhu, Xiao-Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids AKT protein Anticancer properties Apoptosis Autophagy Autophagy - drug effects B cells Biochemistry Biotechnology Breast cancer Cancer Cancer cells Cancer therapies Caspase Cell Biology/Cell Signaling Cell death Cell Line, Tumor Cytokines Cytotoxicity Endothelium Gene Expression Regulation, Neoplastic - drug effects Growth factors Homeostasis Humans Investigations Kinases Laboratories Metabolism Microtubule-Associated Proteins - metabolism Mortality Oncology Oncology/Oncology Agents Pathogenesis Phagocytosis Proteins Proteolysis Proto-Oncogene Proteins c-akt - metabolism Regulation Rhabdastrella Signal Transduction - drug effects Transfection Triterpenes - pharmacology Tumor cell lines Tumorigenesis
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