Altered ultrasonic vocalization and impaired learning and memory in Angelman syndrome mouse model with a large maternal deletion from Ube3a to Gabrb3

Angelman syndrome (AS) is a neurobehavioral disorder associated with mental retardation, absence of language development, characteristic electroencephalography (EEG) abnormalities and epilepsy, happy disposition, movement or balance disorders, and autistic behaviors. The molecular defects underlying...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2010-08, Vol.5 (8), p.e12278
Hauptverfasser:	Jiang, Yong-Hui, Pan, Yanzhen, Zhu, Li, Landa, Luis, Yoo, Jong, Spencer, Corinne, Lorenzo, Isabel, Brilliant, Murray, Noebels, Jeffrey, Beaudet, Arthur L
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Adenosine Triphosphatases - deficiency Adenosine Triphosphatases - genetics Analysis Angelman Syndrome - genetics Angelman Syndrome - physiopathology Animal models Animals Anxiety Autism Behavior Brain Cerebral Cortex - physiopathology Chromosome 15 Chromosome Deletion Chromosomes Cleft lip/palate Comparative studies Darkness Defects Deletion mutant Disease Models, Animal EEG Electroencephalography Epilepsy Exploratory Behavior Female Gene deletion Gene Expression Regulation Genes Genetics and Genomics/Disease Models Genetics and Genomics/Epigenetics Genetics and Genomics/Gene Function Genetics and Genomics/Medical Genetics Genotype & phenotype Homozygote House mouse Human behavior Imprinting Laboratories Language acquisition Male Medicine Membrane Transport Proteins - deficiency Membrane Transport Proteins - genetics Memory Memory tasks Mental disorders Mental task performance Mice Mothers Motor Activity - genetics Motor skill learning Mutation Neonates Neurobiology Neurosciences Patients Pediatrics Phosphorylation Physicians Receptors, GABA-A - deficiency Receptors, GABA-A - genetics Rodents Seizures Seizures - genetics Signaling Studies Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligases - deficiency Ubiquitin-Protein Ligases - genetics Ultrasonics Underpotential deposition Uniparental disomy Vocalization behavior Vocalization, Animal
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!