Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancer

The PI3K-Akt signal pathway plays a key role in tumorigenesis and the development of drug-resistance. Cytotoxic chemotherapy resistance is linked to limited therapeutic options and poor prognosis. Examination of FOXO3a and phosphorylated-Akt (P-Akt) expression in breast cancer tissue microarrays sho...

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Veröffentlicht in:	PloS one 2010-08, Vol.5 (8), p.e12293
Hauptverfasser:	Chen, Jie, Gomes, Ana R, Monteiro, Lara J, Wong, San Yu, Wu, Lai Han, Ng, Ting-Ting, Karadedou, Christina T, Millour, Julie, Ip, Ying-Chi, Cheung, Yuen Nei, Sunters, Andrew, Chan, Kelvin Y K, Lam, Eric W-F, Khoo, Ui-Soon
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Active Transport, Cell Nucleus - drug effects AKT protein Analysis Anthracyclines Apoptosis Breast cancer Breast carcinoma Breast Neoplasms - diagnosis Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cancer therapies Carcinoma, Ductal - diagnosis Carcinoma, Ductal - genetics Carcinoma, Ductal - metabolism Carcinoma, Ductal - pathology Cell culture Cell cycle Cell death Cell Line, Tumor Cell Nucleus - drug effects Cell Nucleus - metabolism Cell proliferation Cell Proliferation - drug effects Chemoresistance Chemotherapy College campuses Colorectal cancer Cytoplasm Cytotoxicity Deregulation Doxorubicin Doxorubicin - pharmacology Drug resistance Drug Resistance, Neoplasm Estrogens Forkhead Box Protein O3 Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism FOXO3 protein Gene Expression Regulation, Neoplastic - drug effects Health aspects Humans Invasiveness Kinases Localization Lymph Lymph nodes Lymphatic Metastasis Medical prognosis Medical research Medicine Metastases Molecular Biology Neoplasm Invasiveness Oncology/Breast Cancer Pathology Pathology/Molecular Pathology Phosphorylation Phosphorylation - drug effects Prognosis Proto-Oncogene Proteins c-akt - metabolism Relocation Signaling Studies Surgery Survival Survival Analysis Tamoxifen Tamoxifen - pharmacology Transcription factors Tumor cell lines Tumorigenesis
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