Hepatic gene expression profiling reveals key pathways involved in leptin-mediated weight loss in ob/ob mice

Leptin, a cytokine-like protein, plays an important role in the regulation of body weight through inhibition of food intake and stimulation of energy expenditure. Leptin circulates in blood and acts on the brain, which sends downstream signals to regulate body weight. Leptin therapy has been success...

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Veröffentlicht in:	PloS one 2010-08, Vol.5 (8), p.e12147
Hauptverfasser:	Sharma, Ashok, Bartell, Shoshana M, Baile, Clifton A, Chen, Bo, Podolsky, Robert H, McIndoe, Richard A, She, Jin-Xiong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipocytes - drug effects Adipocytes - pathology Animal models Animals Biological activity Biomarkers Biotechnology Body fat Body weight Body Weight - drug effects Body weight loss Brain Breast cancer Cancer therapies Carboxylic acids Carboxylic Acids - metabolism Cell Differentiation - drug effects Cell Proliferation - drug effects Cluster Analysis Compartments Cytokines Diabetes and Endocrinology/Obesity DNA microarrays Down-Regulation - drug effects Drug Administration Routes Eating - drug effects Endoplasmic reticulum Energy expenditure Female Food Food intake Gene expression Gene Expression Profiling Genes Genetic research Genetics and Genomics Genetics and Genomics/Gene Expression Genetics and Genomics/Gene Function Genetics and Genomics/Genomics Glutathione Glutathione Transferase - metabolism Homeostasis Hypothalamus Hypothalamus - drug effects Hypothalamus - metabolism Immune system Inflammation Inflammation - metabolism Inflammatory response Insulin - blood Insulin resistance Insulin-like growth factors Iron Iron - metabolism Leptin Leptin - administration & dosage Leptin - pharmacology Lipid Metabolism - drug effects Liver Liver - drug effects Liver - metabolism Lymphatic system Lysosomes - drug effects Lysosomes - metabolism Medicine Metabolic pathways Metabolism Metastasis Mice Mitochondria Mitochondria - drug effects Mitochondria - metabolism Obesity Obesity - genetics Obesity - immunology Obesity - metabolism Obesity - physiopathology Oligonucleotide Array Sequence Analysis Pathways Proteins Rodents Transferases Trends Weight control Weight loss Weight Loss - drug effects Weight Loss - genetics
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