Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis

TGR5, the G protein-coupled bile acid receptor 1 (GPBAR1), has been linked to inflammatory pathways as well as bile homeostasis, and could therefore be involved in primary sclerosing cholangitis (PSC) a chronic inflammatory bile duct disease. We aimed to extensively investigate TGR5 sequence variati...

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Veröffentlicht in:	PloS one 2010-08, Vol.5 (8), p.e12403-e12403
Hauptverfasser:	Hov, Johannes R, Keitel, Verena, Laerdahl, Jon K, Spomer, Lina, Ellinghaus, Eva, ElSharawy, Abdou, Melum, Espen, Boberg, Kirsten M, Manke, Thomas, Balschun, Tobias, Schramm, Christoph, Bergquist, Annika, Weismüller, Tobias, Gotthardt, Daniel, Rust, Christian, Henckaerts, Liesbet, Onnie, Clive M, Weersma, Rinse K, Sterneck, Martina, Teufel, Andreas, Runz, Heiko, Stiehl, Adolf, Ponsioen, Cyriel Y, Wijmenga, Cisca, Vatn, Morten H, Stokkers, Pieter C F, Vermeire, Severine, Mathew, Christopher G, Lie, Benedicte A, Beuers, Ulrich, Manns, Michael P, Schreiber, Stefan, Schrumpf, Erik, Häussinger, Dieter, Franke, Andre, Karlsen, Tom H
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Adenosine Adolescent Adult Aged Amino Acid Sequence Amino acids Analysis Animals Bile Bile duct Bile ducts Cattle Celiac disease Cell lines Child Cholangitis Cholangitis, Sclerosing - complications Cholangitis, Sclerosing - genetics Cholangitis, Sclerosing - metabolism Chromosome 2 Chromosomes, Human, Pair 2 - genetics Clinical medicine Colitis, Ulcerative - complications Confidence intervals Confocal microscopy Cyclic adenosine monophosphate Cystic fibrosis Cytokines Cytometry Deoxycholic acid DNA Mutational Analysis Dogs Endocrinology Epithelial cells Female Flow cytometry G proteins Gallbladder Gastroenterology Gastroenterology and Hepatology/Biliary Tract Gastroenterology and Hepatology/Inflammatory Bowel Disease Gene expression Gene Expression Regulation Gene mapping Genetic aspects Genetics Genetics and Genomics/Complex Traits Genetics and Genomics/Gene Function Genetics and Genomics/Genetics of Disease Hepatology Homeostasis Hospitals Humans Inflammatory bowel disease Internal medicine Linkage disequilibrium Liver diseases Luciferase Male Medical research Medical schools Medicin och hälsovetenskap Medicine Mice Microscopy Middle Aged Models, Molecular Molecular biology Mutation Polymorphism Protein Conformation Proteins Receptors, G-Protein-Coupled - chemistry Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Rodents Single nucleotide polymorphisms Single-nucleotide polymorphism Surgery Young Adult
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