Control of centrin stability by Aurora A

Aurora A is an oncogenic serine/threonine kinase which can cause cell transformation and centrosome amplification when over-expressed. Human breast tumors show excess Aurora A and phospho-centrin in amplified centrosomes. Here, we show that Aurora A mediates the phosphorylation of and localizes with...

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Veröffentlicht in:	PloS one 2011-06, Vol.6 (6), p.e21291-e21291
Hauptverfasser:	Lukasiewicz, Kara B, Greenwood, Tammy M, Negron, Vivian C, Bruzek, Amy K, Salisbury, Jeffrey L, Lingle, Wilma L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomatous polyposis coli Amplification Anaphase-Promoting Complex-Cyclosome Aurora Kinases Biochemistry Biology Breast cancer Calcium-Binding Proteins - metabolism Cancer Cell cycle Cell Cycle Proteins - metabolism Cell Proliferation Centrosome - metabolism Centrosomes Control stability Deoxyribonucleic acid DNA Genetic transformation HeLa Cells Humans Kinases Laboratories Medicine Metaphase Microscopy Mitosis Molecular biology Mutation Mutation - genetics Overexpression Pathology Phosphorylation Prophase Proteasomes Protein Binding Protein Stability Protein Transport Protein-Serine-Threonine Kinases - metabolism Protein-serine/threonine kinase Proteins Regulation Serine - metabolism Threonine Transformation Tumors Ubiquitin-Protein Ligase Complexes - metabolism
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