The regulation of miRNA-211 expression and its role in melanoma cell invasiveness

The immediate molecular mechanisms behind invasive melanoma are poorly understood. Recent studies implicate microRNAs (miRNAs) as important agents in melanoma and other cancers. To investigate the role of miRNAs in melanoma, we subjected human melanoma cell lines to miRNA expression profiling, and r...

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Veröffentlicht in:	PloS one 2010-11, Vol.5 (11), p.e13779-e13779
Hauptverfasser:	Mazar, Joseph, DeYoung, Katherine, Khaitan, Divya, Meister, Edward, Almodovar, Alvin, Goydos, James, Ray, Animesh, Perera, Ranjan J
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions 3' Untranslated Regions - genetics Apoptosis Binding sites Binding Sites - genetics Biotechnology Blotting, Western Brain tumors Breast cancer Cancer metastasis Cancer therapies Cell cycle Cell growth Cell Line Cell Line, Tumor Cell Proliferation Cells, Cultured Cleavage Coding Comparative analysis Deoxyribonucleic acid DNA DNA methylation Epigenetics Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene sequencing Genetics and Genomics/Cancer Genetics Genetics and Genomics/Functional Genomics Genetics and Genomics/Gene Discovery Genetics and Genomics/Gene Expression Genomes Glioma Humans Introns - genetics Invasiveness Kinases Large-Conductance Calcium-Activated Potassium Channel alpha Subunits - genetics Large-Conductance Calcium-Activated Potassium Channel alpha Subunits - metabolism Medical research Melanocytes Melanoma Melanoma - genetics Melanoma - pathology Metastases Metastasis Microphthalmia-associated transcription factor MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Molecular modelling Mutation Neoplasm Invasiveness Oligonucleotide Array Sequence Analysis Post-transcription Prostate cancer Proteins Reverse Transcriptase Polymerase Chain Reaction RNA Interference Signal transduction Skin cancer Stem cells Transcription factors Transient receptor potential proteins TRPM Cation Channels - genetics
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