HLA-DM mediates epitope selection by a "compare-exchange" mechanism when a potential peptide pool is available

HLA-DM (DM) mediates exchange of peptides bound to MHC class II (MHCII) during the epitope selection process. Although DM has been shown to have two activities, peptide release and MHC class II refolding, a clear characterization of the mechanism by which DM facilitates peptide exchange has remained...

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Veröffentlicht in:	PloS one 2008-11, Vol.3 (11), p.e3722
Hauptverfasser:	Ferrante, Andrea, Anderson, Matthew W, Klug, Candice S, Gorski, Jack
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen Presentation - physiology Antigenic determinants Antigens Binding Binding sites Biochemistry/Biomacromolecule-Ligand Interactions Biophysics/Protein Folding Catalysis Classification Dissociation Electron paramagnetic resonance Electron Spin Resonance Spectroscopy Endoplasmic reticulum Energy transfer Epitopes Epitopes - chemistry Exchanging Fluorescence Fluorescence Polarization Folding Genes, MHC Class II - physiology Histocompatibility antigen HLA HLA-D Antigens - metabolism Immunology/Antigen Processing and Recognition Influenza Major histocompatibility complex Peptides Peptides - genetics Peptides - metabolism Peptides - pharmacokinetics Protein Binding - physiology Protein Conformation Protein Folding Proteins Sorting algorithms Studies
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