Systems biology of coagulation initiation: kinetics of thrombin generation in resting and activated human blood

Blood function defines bleeding and clotting risks and dictates approaches for clinical intervention. Independent of adding exogenous tissue factor (TF), human blood treated in vitro with corn trypsin inhibitor (CTI, to block Factor XIIa) will generate thrombin after an initiation time (T(i)) of 1 t...

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Veröffentlicht in:	PLoS computational biology 2010-09, Vol.6 (9), p.e1000950
Hauptverfasser:	Chatterjee, Manash S, Denney, William S, Jing, Huiyan, Diamond, Scott L
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology Biotechnology/Bioengineering Blood clots Blood clotting Blood Coagulation - drug effects Blood Coagulation - physiology Blood Coagulation Factors - metabolism Blood platelets Cardiovascular Disorders/Vascular Biology Coagulation Computer Simulation Crotalid Venoms - pharmacology Experiments Factor XIIa - metabolism Fibrinolytic Agents - pharmacology Fluorescent Dyes High-Throughput Screening Assays Humans Immunoassay Kinetics Lectins, C-Type Metabolic Networks and Pathways - drug effects Metabolic Networks and Pathways - physiology Ordinary differential equations Physiological aspects Plant Proteins - pharmacology Plasma Platelet Activation - drug effects Platelet Activation - physiology Proteins Reproducibility of Results Sensitivity analysis Systems biology Systems Biology - methods Thrombin Thrombin - metabolism Thromboplastin - metabolism Trypsin inhibitors
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