MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus

We previously reported that the G allele of rs3853839 at 3'untranslated region (UTR) of Toll-like receptor 7 (TLR7) was associated with elevated transcript expression and increased risk for systemic lupus erythematosus (SLE) in 9,274 Eastern Asians [P = 6.5×10(-10), odds ratio (OR) (95%CI) = 1....

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Veröffentlicht in:	PLoS genetics 2013-02, Vol.9 (2), p.e1003336-e1003336
Hauptverfasser:	Deng, Yun, Zhao, Jian, Sakurai, Daisuke, Kaufman, Kenneth M, Edberg, Jeffrey C, Kimberly, Robert P, Kamen, Diane L, Gilkeson, Gary S, Jacob, Chaim O, Scofield, R Hal, Langefeld, Carl D, Kelly, Jennifer A, Ramsey-Goldman, Rosalind, Petri, Michelle A, Reveille, John D, Vilá, Luis M, Alarcón, Graciela S, Vyse, Timothy J, Pons-Estel, Bernardo A, Freedman, Barry I, Gaffney, Patrick M, Sivils, Kathy Moser, James, Judith A, Gregersen, Peter K, Anaya, Juan-Manuel, Niewold, Timothy B, Merrill, Joan T, Criswell, Lindsey A, Stevens, Anne M, Boackle, Susan A, Cantor, Rita M, Chen, Weiling, Grossman, Jeniffer M, Hahn, Bevra H, Harley, John B, Alarcόn-Riquelme, Marta E, Brown, Elizabeth E, Tsao, Betty P
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions African Americans - genetics Alleles Allelomorphism Asian Continental Ancestry Group - genetics Autoimmune diseases Biology European Continental Ancestry Group Gene expression Gene Expression Regulation - genetics Genes Genetic aspects Genetic Predisposition to Disease Genetic variation Health aspects HEK293 Cells Hispanic Americans - genetics Humans Immune system Lupus Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - metabolism Medicine MicroRNA MicroRNAs - genetics Physiological aspects Polymorphism, Single Nucleotide Proteins Systemic lupus erythematosus Toll-Like Receptor 7 - genetics Toll-Like Receptor 7 - metabolism Toll-like receptors
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