Rearrangements of 2.5 kilobases of noncoding DNA from the Drosophila even-skipped locus define predictive rules of genomic cis-regulatory logic

Rearrangements of about 2.5 kilobases of regulatory DNA located 5' of the transcription start site of the Drosophila even-skipped locus generate large-scale changes in the expression of even-skipped stripes 2, 3, and 7. The most radical effects are generated by juxtaposing the minimal stripe en...

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Veröffentlicht in:	PLoS genetics 2013-02, Vol.9 (2), p.e1003243
Hauptverfasser:	Kim, Ah-Ram, Martinez, Carlos, Ionides, John, Ramos, Alexandre F, Ludwig, Michael Z, Ogawa, Nobuo, Sharp, David H, Reinitz, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BASIC BIOLOGICAL SCIENCES Binding Sites Biology Computer Science Deoxyribonucleic acid DNA DNA sequencing DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drosophila Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - genetics Enhancer Elements, Genetic Evolution, Molecular Gene expression Gene Expression Regulation, Developmental Gene Rearrangement - genetics Genetic aspects Genetics Genetics & Heredity Genome Genomics Health aspects Homeodomain Proteins - genetics Mathematics Noncoding DNA Nucleotide sequencing Physiological aspects Proteins Quantitative genetics RNA, Untranslated - genetics Transcription Factors - genetics Transcription Initiation Site
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