Lysis of endogenously infected CD4+ T cell blasts by rIL-2 activated autologous natural killer cells from HIV-infected viremic individuals

Understanding the cellular mechanisms that ensure an appropriate innate immune response against viral pathogens is an important challenge of biomedical research. In vitro studies have shown that natural killer (NK) cells purified from healthy donors can kill heterologous cell lines or autologous CD4...

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Veröffentlicht in:	PLoS pathogens 2008-07, Vol.4 (7), p.e1000101-e1000101
Hauptverfasser:	Fogli, Manuela, Mavilio, Domenico, Brunetta, Enrico, Varchetta, Stefania, Ata, Khaled, Roby, Gregg, Kovacs, Colin, Follmann, Dean, Pende, Daniela, Ward, Jeffrey, Barker, Edward, Marcenaro, Emanuela, Moretta, Alessandro, Fauci, Anthony S
Format:	Artikel
Sprache:	eng
Schlagworte:	CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - virology Cell Proliferation Cells Cytotoxicity, Immunologic HIV Core Protein p24 - immunology HIV Infections - blood HIV Infections - immunology HLA-A Antigens - metabolism HLA-B Antigens - metabolism Human immunodeficiency virus 1 Humans Immune system Immunology Immunology/Immunity to Infections Immunology/Innate Immunity Infectious Diseases/HIV Infection and AIDS Interleukin-2 - immunology Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Killer Cells, Natural - virology Monocytes, Activated Killer - immunology Monocytes, Activated Killer - metabolism Monocytes, Activated Killer - virology Proteins Recombinant Proteins Virus Replication
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