Interleukin-7 facilitates HIV-1 transmission to cervico-vaginal tissue ex vivo

The majority of HIV-1 infections in women occur through vaginal intercourse, in which virus-containing semen is deposited on the cervico-vaginal mucosa. Semen is more than a mere carrier of HIV-1, since it contains many biological factors, in particular cytokines, that may affect HIV-1 transmission....

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Veröffentlicht in:	PLoS pathogens 2013-02, Vol.9 (2), p.e1003148-e1003148
Hauptverfasser:	Introini, Andrea, Vanpouille, Christophe, Lisco, Andrea, Grivel, Jean-Charles, Margolis, Leonid
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Apoptosis Apoptosis Regulatory Proteins - metabolism Biology CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - virology Cell Proliferation Cervix Uteri - virology Colleges & universities Disease transmission Experiments Female Gene Expression Regulation, Viral Health aspects HIV HIV infection HIV Infections - transmission HIV Infections - virology HIV-1 - physiology Human immunodeficiency virus Humans Interleukin-7 - metabolism Interleukins Ki-67 Antigen - metabolism Lymphocytes Lymphoid Tissue - virology Male Medicine Molecular Sequence Data Palatine Tonsil - virology Physiological aspects Plasma Proteins Proto-Oncogene Proteins c-bcl-2 - metabolism Recombinant Proteins Sexual intercourse Statistical analysis Vagina - virology Virus Replication
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