Plasmodium falciparum malaria elicits inflammatory responses that dysregulate placental amino acid transport
Placental malaria (PM) can lead to poor neonatal outcomes, including low birthweight due to fetal growth restriction (FGR), especially when associated with local inflammation (intervillositis or IV). The pathogenesis of PM-associated FGR is largely unknown, but in idiopathic FGR, impaired transplace...
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| creator | Boeuf, Philippe Aitken, Elizabeth H Chandrasiri, Upeksha Chua, Caroline Lin Lin McInerney, Bernie McQuade, Leon Duffy, Michael Molyneux, Malcolm Brown, Graham Glazier, Jocelyn Rogerson, Stephen J |
| description | Placental malaria (PM) can lead to poor neonatal outcomes, including low birthweight due to fetal growth restriction (FGR), especially when associated with local inflammation (intervillositis or IV). The pathogenesis of PM-associated FGR is largely unknown, but in idiopathic FGR, impaired transplacental amino acid transport, especially through the system A group of amino acid transporters, has been implicated. We hypothesized that PM-associated FGR could result from impairment of transplacental amino acid transport triggered by IV. In a cohort of Malawian women and their infants, the expression and activity of system A (measured by Na⁺-dependent ¹⁴C-MeAIB uptake) were reduced in PM, especially when associated with IV, compared to uninfected placentas. In an in vitro model of PM with IV, placental cells exposed to monocyte/infected erythrocytes conditioned medium showed decreased system A activity. Amino acid concentrations analyzed by reversed phase ultra performance liquid chromatography in paired maternal and cord plasmas revealed specific alterations of amino acid transport by PM, especially with IV. Overall, our data suggest that the fetoplacental unit responds to PM by altering its placental amino acid transport to maintain adequate fetal growth. However, IV more profoundly compromises placental amino acid transport function, leading to FGR. Our study offers the first pathogenetic explanation for FGR in PM. |
| doi_str_mv | 10.1371/journal.ppat.1003153 |
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The pathogenesis of PM-associated FGR is largely unknown, but in idiopathic FGR, impaired transplacental amino acid transport, especially through the system A group of amino acid transporters, has been implicated. We hypothesized that PM-associated FGR could result from impairment of transplacental amino acid transport triggered by IV. In a cohort of Malawian women and their infants, the expression and activity of system A (measured by Na⁺-dependent ¹⁴C-MeAIB uptake) were reduced in PM, especially when associated with IV, compared to uninfected placentas. In an in vitro model of PM with IV, placental cells exposed to monocyte/infected erythrocytes conditioned medium showed decreased system A activity. Amino acid concentrations analyzed by reversed phase ultra performance liquid chromatography in paired maternal and cord plasmas revealed specific alterations of amino acid transport by PM, especially with IV. Overall, our data suggest that the fetoplacental unit responds to PM by altering its placental amino acid transport to maintain adequate fetal growth. However, IV more profoundly compromises placental amino acid transport function, leading to FGR. Our study offers the first pathogenetic explanation for FGR in PM.</description><identifier>ISSN: 1553-7374</identifier><identifier>ISSN: 1553-7366</identifier><identifier>EISSN: 1553-7374</identifier><identifier>DOI: 10.1371/journal.ppat.1003153</identifier><identifier>PMID: 23408887</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Amino Acid Transport System A - genetics ; Amino Acid Transport System A - metabolism ; Amino acids ; Amino Acids - analysis ; Amino Acids - metabolism ; Biological Transport ; Biology ; Blood & organ donations ; Case-Control Studies ; Cell Line, Tumor ; Cohort Studies ; Female ; Fetal Growth Retardation - etiology ; Fetal Growth Retardation - immunology ; Fetal Growth Retardation - metabolism ; Fetus ; Growth ; Health aspects ; Host-parasite relationships ; Humans ; Infant ; Infant, Low Birth Weight ; Infant, Newborn ; Infections ; Inflammation ; Interleukin-1beta - blood ; Interleukin-1beta - metabolism ; Liquid chromatography ; Malaria ; Malaria, Falciparum - complications ; Malaria, Falciparum - immunology ; Malaria, Falciparum - metabolism ; Malawi ; Maternal-Fetal Exchange - immunology ; Medical research ; Medicine ; Monocytes ; Pathogenesis ; Physiological aspects ; Placenta - immunology ; Placenta - metabolism ; Placenta Diseases - immunology ; Placenta Diseases - metabolism ; Plasmodium falciparum ; Plasmodium falciparum - immunology ; Plasmodium falciparum - physiology ; Pregnancy ; Pregnancy Complications, Parasitic - immunology ; Pregnancy Complications, Parasitic - metabolism ; Statistical analysis ; Vector-borne diseases ; Womens health ; Young Adult</subject><ispartof>PLoS pathogens, 2013-02, Vol.9 (2), p.e1003153-e1003153</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Boeuf et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Boeuf P, Aitken EH, Chandrasiri U, Chua CLL, McInerney B, et al. (2013) Plasmodium falciparum Malaria Elicits Inflammatory Responses that Dysregulate Placental Amino Acid Transport. PLoS Pathog 9(2): e1003153. doi:10.1371/journal.ppat.1003153</rights><rights>2013 Boeuf et al 2013 Boeuf et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c661t-c664d0686ddaf64cc57c3989b2fde9939d712b87ec7d3e2646cfd623ea5cd47b3</citedby><cites>FETCH-LOGICAL-c661t-c664d0686ddaf64cc57c3989b2fde9939d712b87ec7d3e2646cfd623ea5cd47b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567154/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567154/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23871,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23408887$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Kazura, James W.</contributor><creatorcontrib>Boeuf, Philippe</creatorcontrib><creatorcontrib>Aitken, Elizabeth H</creatorcontrib><creatorcontrib>Chandrasiri, Upeksha</creatorcontrib><creatorcontrib>Chua, Caroline Lin Lin</creatorcontrib><creatorcontrib>McInerney, Bernie</creatorcontrib><creatorcontrib>McQuade, Leon</creatorcontrib><creatorcontrib>Duffy, Michael</creatorcontrib><creatorcontrib>Molyneux, Malcolm</creatorcontrib><creatorcontrib>Brown, Graham</creatorcontrib><creatorcontrib>Glazier, Jocelyn</creatorcontrib><creatorcontrib>Rogerson, Stephen J</creatorcontrib><title>Plasmodium falciparum malaria elicits inflammatory responses that dysregulate placental amino acid transport</title><title>PLoS pathogens</title><addtitle>PLoS Pathog</addtitle><description>Placental malaria (PM) can lead to poor neonatal outcomes, including low birthweight due to fetal growth restriction (FGR), especially when associated with local inflammation (intervillositis or IV). The pathogenesis of PM-associated FGR is largely unknown, but in idiopathic FGR, impaired transplacental amino acid transport, especially through the system A group of amino acid transporters, has been implicated. We hypothesized that PM-associated FGR could result from impairment of transplacental amino acid transport triggered by IV. In a cohort of Malawian women and their infants, the expression and activity of system A (measured by Na⁺-dependent ¹⁴C-MeAIB uptake) were reduced in PM, especially when associated with IV, compared to uninfected placentas. In an in vitro model of PM with IV, placental cells exposed to monocyte/infected erythrocytes conditioned medium showed decreased system A activity. Amino acid concentrations analyzed by reversed phase ultra performance liquid chromatography in paired maternal and cord plasmas revealed specific alterations of amino acid transport by PM, especially with IV. Overall, our data suggest that the fetoplacental unit responds to PM by altering its placental amino acid transport to maintain adequate fetal growth. However, IV more profoundly compromises placental amino acid transport function, leading to FGR. Our study offers the first pathogenetic explanation for FGR in PM.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Amino Acid Transport System A - genetics</subject><subject>Amino Acid Transport System A - metabolism</subject><subject>Amino acids</subject><subject>Amino Acids - analysis</subject><subject>Amino Acids - metabolism</subject><subject>Biological Transport</subject><subject>Biology</subject><subject>Blood & organ donations</subject><subject>Case-Control Studies</subject><subject>Cell Line, Tumor</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Fetal Growth Retardation - etiology</subject><subject>Fetal Growth Retardation - immunology</subject><subject>Fetal Growth Retardation - metabolism</subject><subject>Fetus</subject><subject>Growth</subject><subject>Health aspects</subject><subject>Host-parasite relationships</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Low Birth Weight</subject><subject>Infant, Newborn</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Interleukin-1beta - blood</subject><subject>Interleukin-1beta - metabolism</subject><subject>Liquid chromatography</subject><subject>Malaria</subject><subject>Malaria, Falciparum - complications</subject><subject>Malaria, Falciparum - immunology</subject><subject>Malaria, Falciparum - metabolism</subject><subject>Malawi</subject><subject>Maternal-Fetal Exchange - immunology</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Monocytes</subject><subject>Pathogenesis</subject><subject>Physiological aspects</subject><subject>Placenta - immunology</subject><subject>Placenta - metabolism</subject><subject>Placenta Diseases - immunology</subject><subject>Placenta Diseases - metabolism</subject><subject>Plasmodium falciparum</subject><subject>Plasmodium falciparum - immunology</subject><subject>Plasmodium falciparum - physiology</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Parasitic - immunology</subject><subject>Pregnancy Complications, Parasitic - metabolism</subject><subject>Statistical analysis</subject><subject>Vector-borne diseases</subject><subject>Womens health</subject><subject>Young Adult</subject><issn>1553-7374</issn><issn>1553-7366</issn><issn>1553-7374</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqVkktv1DAUhSMEoqXwDxBEYgOLGfyKnWyQqorHSBUgHmvrxnamHjlxajuI-fc4TFp1UDcokmM53znX5-YWxXOM1pgK_HbnpzCAW48jpDVGiOKKPihOcVXRlaCCPbyzPymexLhDiGGK-ePihFCG6roWp4X76iD2XtupLztwyo4Q8rYHB8FCaZxVNsXSDp2Dvofkw74MJo5-iCaW6QpSqfcxmO3kIJlydKDMkMCV0NvBl6CsLlOAIStCelo8yjWieba8z4qfH97_uPi0uvzycXNxfrlSnOM0r0wjXnOtoeNMqUoo2tRNSzptmoY2WmDS1sIooakhnHHVaU6ogUppJlp6Vrw8-I7OR7k0KsocnlHGBKGZ2BwI7WEnx2B7CHvpwcq_Bz5sJYRklTOSUEwQaTXmLWNVI6AxgHDdChAIE1Fnr3dLtantjZ7zB3BHpsdfBnslt_6XpBUXuGLZ4PViEPz1ZGKSvY3KOAeD8VO-N6nrfImqwRl99Q96f7qF2kIOkP-dz3XVbCrPKcmdrJsKZWp9D5UfbXqr_GA6m8-PBG-OBJlJ5nfawhSj3Hz_9h_s52OWHVgVfMyz1N32DiM5z_pNSDnPulxmPcte3O37rehmuOkfiXL8Mw</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Boeuf, Philippe</creator><creator>Aitken, Elizabeth H</creator><creator>Chandrasiri, Upeksha</creator><creator>Chua, Caroline Lin Lin</creator><creator>McInerney, Bernie</creator><creator>McQuade, Leon</creator><creator>Duffy, Michael</creator><creator>Molyneux, Malcolm</creator><creator>Brown, Graham</creator><creator>Glazier, Jocelyn</creator><creator>Rogerson, Stephen J</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISN</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130201</creationdate><title>Plasmodium falciparum malaria elicits inflammatory responses that dysregulate placental amino acid transport</title><author>Boeuf, Philippe ; Aitken, Elizabeth H ; Chandrasiri, Upeksha ; Chua, Caroline Lin Lin ; McInerney, Bernie ; McQuade, Leon ; Duffy, Michael ; Molyneux, Malcolm ; Brown, Graham ; Glazier, Jocelyn ; Rogerson, Stephen J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c661t-c664d0686ddaf64cc57c3989b2fde9939d712b87ec7d3e2646cfd623ea5cd47b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Amino Acid Transport System A - genetics</topic><topic>Amino Acid Transport System A - metabolism</topic><topic>Amino acids</topic><topic>Amino Acids - analysis</topic><topic>Amino Acids - metabolism</topic><topic>Biological Transport</topic><topic>Biology</topic><topic>Blood & organ donations</topic><topic>Case-Control Studies</topic><topic>Cell Line, Tumor</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Fetal Growth Retardation - etiology</topic><topic>Fetal Growth Retardation - immunology</topic><topic>Fetal Growth Retardation - metabolism</topic><topic>Fetus</topic><topic>Growth</topic><topic>Health aspects</topic><topic>Host-parasite relationships</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Low Birth Weight</topic><topic>Infant, Newborn</topic><topic>Infections</topic><topic>Inflammation</topic><topic>Interleukin-1beta - blood</topic><topic>Interleukin-1beta - metabolism</topic><topic>Liquid chromatography</topic><topic>Malaria</topic><topic>Malaria, Falciparum - complications</topic><topic>Malaria, Falciparum - immunology</topic><topic>Malaria, Falciparum - metabolism</topic><topic>Malawi</topic><topic>Maternal-Fetal Exchange - immunology</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Monocytes</topic><topic>Pathogenesis</topic><topic>Physiological aspects</topic><topic>Placenta - immunology</topic><topic>Placenta - metabolism</topic><topic>Placenta Diseases - immunology</topic><topic>Placenta Diseases - metabolism</topic><topic>Plasmodium falciparum</topic><topic>Plasmodium falciparum - immunology</topic><topic>Plasmodium falciparum - physiology</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Parasitic - immunology</topic><topic>Pregnancy Complications, Parasitic - metabolism</topic><topic>Statistical analysis</topic><topic>Vector-borne diseases</topic><topic>Womens health</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boeuf, Philippe</creatorcontrib><creatorcontrib>Aitken, Elizabeth H</creatorcontrib><creatorcontrib>Chandrasiri, Upeksha</creatorcontrib><creatorcontrib>Chua, Caroline Lin Lin</creatorcontrib><creatorcontrib>McInerney, Bernie</creatorcontrib><creatorcontrib>McQuade, Leon</creatorcontrib><creatorcontrib>Duffy, Michael</creatorcontrib><creatorcontrib>Molyneux, Malcolm</creatorcontrib><creatorcontrib>Brown, Graham</creatorcontrib><creatorcontrib>Glazier, Jocelyn</creatorcontrib><creatorcontrib>Rogerson, Stephen J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Canada</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>Proquest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS pathogens</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boeuf, Philippe</au><au>Aitken, Elizabeth H</au><au>Chandrasiri, Upeksha</au><au>Chua, Caroline Lin Lin</au><au>McInerney, Bernie</au><au>McQuade, Leon</au><au>Duffy, Michael</au><au>Molyneux, Malcolm</au><au>Brown, Graham</au><au>Glazier, Jocelyn</au><au>Rogerson, Stephen J</au><au>Kazura, James W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasmodium falciparum malaria elicits inflammatory responses that dysregulate placental amino acid transport</atitle><jtitle>PLoS pathogens</jtitle><addtitle>PLoS Pathog</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>9</volume><issue>2</issue><spage>e1003153</spage><epage>e1003153</epage><pages>e1003153-e1003153</pages><issn>1553-7374</issn><issn>1553-7366</issn><eissn>1553-7374</eissn><abstract>Placental malaria (PM) can lead to poor neonatal outcomes, including low birthweight due to fetal growth restriction (FGR), especially when associated with local inflammation (intervillositis or IV). The pathogenesis of PM-associated FGR is largely unknown, but in idiopathic FGR, impaired transplacental amino acid transport, especially through the system A group of amino acid transporters, has been implicated. We hypothesized that PM-associated FGR could result from impairment of transplacental amino acid transport triggered by IV. In a cohort of Malawian women and their infants, the expression and activity of system A (measured by Na⁺-dependent ¹⁴C-MeAIB uptake) were reduced in PM, especially when associated with IV, compared to uninfected placentas. In an in vitro model of PM with IV, placental cells exposed to monocyte/infected erythrocytes conditioned medium showed decreased system A activity. Amino acid concentrations analyzed by reversed phase ultra performance liquid chromatography in paired maternal and cord plasmas revealed specific alterations of amino acid transport by PM, especially with IV. Overall, our data suggest that the fetoplacental unit responds to PM by altering its placental amino acid transport to maintain adequate fetal growth. However, IV more profoundly compromises placental amino acid transport function, leading to FGR. Our study offers the first pathogenetic explanation for FGR in PM.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23408887</pmid><doi>10.1371/journal.ppat.1003153</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1553-7374 |
| ispartof | PLoS pathogens, 2013-02, Vol.9 (2), p.e1003153-e1003153 |
| issn | 1553-7374 1553-7366 1553-7374 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Public Library of Science (PLoS) Journals Open Access; PubMed Central |
| subjects | Adolescent Adult Amino Acid Transport System A - genetics Amino Acid Transport System A - metabolism Amino acids Amino Acids - analysis Amino Acids - metabolism Biological Transport Biology Blood & organ donations Case-Control Studies Cell Line, Tumor Cohort Studies Female Fetal Growth Retardation - etiology Fetal Growth Retardation - immunology Fetal Growth Retardation - metabolism Fetus Growth Health aspects Host-parasite relationships Humans Infant Infant, Low Birth Weight Infant, Newborn Infections Inflammation Interleukin-1beta - blood Interleukin-1beta - metabolism Liquid chromatography Malaria Malaria, Falciparum - complications Malaria, Falciparum - immunology Malaria, Falciparum - metabolism Malawi Maternal-Fetal Exchange - immunology Medical research Medicine Monocytes Pathogenesis Physiological aspects Placenta - immunology Placenta - metabolism Placenta Diseases - immunology Placenta Diseases - metabolism Plasmodium falciparum Plasmodium falciparum - immunology Plasmodium falciparum - physiology Pregnancy Pregnancy Complications, Parasitic - immunology Pregnancy Complications, Parasitic - metabolism Statistical analysis Vector-borne diseases Womens health Young Adult |
| title | Plasmodium falciparum malaria elicits inflammatory responses that dysregulate placental amino acid transport |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-14T18%3A31%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Plasmodium%20falciparum%20malaria%20elicits%20inflammatory%20responses%20that%20dysregulate%20placental%20amino%20acid%20transport&rft.jtitle=PLoS%20pathogens&rft.au=Boeuf,%20Philippe&rft.date=2013-02-01&rft.volume=9&rft.issue=2&rft.spage=e1003153&rft.epage=e1003153&rft.pages=e1003153-e1003153&rft.issn=1553-7374&rft.eissn=1553-7374&rft_id=info:doi/10.1371/journal.ppat.1003153&rft_dat=%3Cgale_plos_%3EA329898950%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1314344723&rft_id=info:pmid/23408887&rft_galeid=A329898950&rft_doaj_id=oai_doaj_org_article_231202bd16b44597a9ea018b7a701278&rfr_iscdi=true |