Influenza HA subtypes demonstrate divergent phenotypes for cleavage activation and pH of fusion: implications for host range and adaptation

The influenza A virus (IAV) HA protein must be activated by host cells proteases in order to prime the molecule for fusion. Consequently, the availability of activating proteases and the susceptibility of HA to protease activity represents key factors in facilitating virus infection. As such, unders...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PLoS pathogens 2013-02, Vol.9 (2), p.e1003151-e1003151
Hauptverfasser:	Galloway, Summer E, Reed, Mark L, Russell, Charles J, Steinhauer, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological Animals Biology Birds Genetic aspects Health aspects Hemagglutinin Glycoproteins, Influenza Virus - chemistry Hemagglutinin Glycoproteins, Influenza Virus - classification Hemagglutinin Glycoproteins, Influenza Virus - genetics Hemagglutinin Glycoproteins, Influenza Virus - metabolism Host Specificity Host-parasite relationships Humans Hydrogen-Ion Concentration Immunoprecipitation Influenza A virus - genetics Influenza A virus - pathogenicity Influenza viruses Influenza, Human - metabolism Influenza, Human - pathology Influenza, Human - virology Membrane Fusion - physiology Mutation Pandemics Phenotype Physiological aspects Protein Conformation Proteins Serine Endopeptidases - metabolism Trypsin - metabolism Vero Cells Viral genetics Virus Activation - physiology Virus Replication
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!