UCP2 deficiency helps to restrict the pathogenesis of experimental cutaneous and visceral leishmaniosis in mice

Uncoupling protein 2 (UCP2) is a mitochondrial transporter that has been shown to lower the production of reactive oxygen species (ROS). Intracellular pathogens such as Leishmania upregulate UCP2 and thereby suppress ROS production in infected host tissues, allowing the multiplication of parasites w...

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Veröffentlicht in:	PLoS neglected tropical diseases 2013-02, Vol.7 (2), p.e2077-e2077
Hauptverfasser:	Carrión, Javier, Abengozar, M Angeles, Fernández-Reyes, María, Sánchez-Martín, Carlos, Rial, Eduardo, Domínguez-Bernal, Gustavo, González-Barroso, M Mar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology Care and treatment Cytokines Cytokines - secretion Development and progression Disease Models, Animal Female Health aspects Immune response Immune system Interleukin-12 Ion Channels - deficiency Leishmania infantum - immunology Leishmania infantum - isolation & purification Leishmania infantum - pathogenicity Leishmania major - immunology Leishmania major - isolation & purification Leishmania major - pathogenicity Leishmaniasis Leishmaniasis, Cutaneous - immunology Leishmaniasis, Cutaneous - pathology Leishmaniasis, Visceral - immunology Leishmaniasis, Visceral - pathology Macrophages Medicine Mice Mice, Inbred C57BL Mice, Knockout Mitochondrial Proteins - deficiency Parasite Load Parasites Physiological aspects Proteins Rodents Tropical diseases Uncoupling Protein 2 Veterinary Science
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