Fine tuning inflammation at the front door: macrophage complement receptor 3-mediates phagocytosis and immune suppression for Francisella tularensis

Complement receptor 3 (CR3, CD11b/CD18) is a major macrophage phagocytic receptor. The biochemical pathways through which CR3 regulates immunologic responses have not been fully characterized. Francisella tularensis is a remarkably infectious, facultative intracellular pathogen of macrophages that c...

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Veröffentlicht in:	PLoS pathogens 2013-01, Vol.9 (1), p.e1003114-e1003114
Hauptverfasser:	Dai, Shipan, Rajaram, Murugesan V S, Curry, Heather M, Leander, Rachel, Schlesinger, Larry S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteria Biology CHO Cells - immunology CHO Cells - metabolism Cricetinae Cricetulus Disease Experiments Francisella tularensis Francisella tularensis - immunology Gene Silencing Health aspects Host-parasite relationships Humans Immune Evasion Immune response Immune system Immune Tolerance Immunologic Factors - metabolism Inflammation Inflammation - immunology Inflammation - microbiology Macrophage-1 Antigen - metabolism Macrophages Macrophages - immunology Macrophages - metabolism Macrophages - microbiology Medicine Mortality Opsonin Proteins - metabolism Phagocytosis Phagocytosis - immunology Physiological aspects RNA, Small Interfering - genetics Rodents Transfection Tularemia Tularemia - immunology Tularemia - metabolism
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