Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts

Obesity is associated with vitamin D deficiency, and both are areas of active public health concern. We explored the causality and direction of the relationship between body mass index (BMI) and 25-hydroxyvitamin D [25(OH)D] using genetic markers as instrumental variables (IVs) in bi-directional Men...

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Veröffentlicht in:	PLoS medicine 2013-02, Vol.10 (2), p.e1001383-e1001383
Hauptverfasser:	Vimaleswaran, Karani S, Berry, Diane J, Lu, Chen, Tikkanen, Emmi, Pilz, Stefan, Hiraki, Linda T, Cooper, Jason D, Dastani, Zari, Li, Rui, Houston, Denise K, Wood, Andrew R, Michaëlsson, Karl, Vandenput, Liesbeth, Zgaga, Lina, Yerges-Armstrong, Laura M, McCarthy, Mark I, Dupuis, Josée, Kaakinen, Marika, Kleber, Marcus E, Jameson, Karen, Arden, Nigel, Raitakari, Olli, Viikari, Jorma, Lohman, Kurt K, Ferrucci, Luigi, Melhus, Håkan, Ingelsson, Erik, Byberg, Liisa, Lind, Lars, Lorentzon, Mattias, Salomaa, Veikko, Campbell, Harry, Dunlop, Malcolm, Mitchell, Braxton D, Herzig, Karl-Heinz, Pouta, Anneli, Hartikainen, Anna-Liisa, Streeten, Elizabeth A, Theodoratou, Evropi, Jula, Antti, Wareham, Nicholas J, Ohlsson, Claes, Frayling, Timothy M, Kritchevsky, Stephen B, Spector, Timothy D, Richards, J Brent, Lehtimäki, Terho, Ouwehand, Willem H, Kraft, Peter, Cooper, Cyrus, März, Winfried, Power, Chris, Loos, Ruth J F, Wang, Thomas J, Järvelin, Marjo-Riitta, Whittaker, John C, Hingorani, Aroon D, Hyppönen, Elina
Format:	Artikel
Sprache:	eng
Schlagworte:	25-hydroxyvitamin d Adult Aged Aged, 80 and over Alfacalcidol Basic Medicine Biology Biomarkers - blood Body Mass Index Calcifediol cardiovascular-disease risk common obesity d deficiency d insufficiency Endocrinology and Diabetes Endokrinologi och diabetes Europe Evidence-Based Medicine Female Genetic Predisposition to Disease genetic-variants genome-wide association Health aspects Humans instrumental variables Linear Models Male Medicinska grundvetenskaper Mendelian Randomization Analysis Middle Aged Multivariate Analysis North America Obesity Obesity - diagnosis Obesity - ethnology Obesity - genetics Obesity - therapy Phenotype Physiological aspects Polymorphism, Single Nucleotide prevalence Risk Assessment Risk Factors Social medicine Studies Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - diagnosis Vitamin D Deficiency - ethnology Vitamin D Deficiency - genetics Vitamin D Deficiency - prevention & control Whites - genetics
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