Insulin signaling regulates fatty acid catabolism at the level of CoA activation

The insulin/IGF signaling pathway is a highly conserved regulator of metabolism in flies and mammals, regulating multiple physiological functions including lipid metabolism. Although insulin signaling is known to regulate the activity of a number of enzymes in metabolic pathways, a comprehensive und...

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Veröffentlicht in:	PLoS genetics 2012-01, Vol.8 (1), p.e1002478-e1002478
Hauptverfasser:	Xu, Xiaojun, Gopalacharyulu, Peddinti, Seppänen-Laakso, Tuulikki, Ruskeepää, Anna-Liisa, Aye, Cho Cho, Carson, Brian P, Mora, Silvia, Orešič, Matej, Teleman, Aurelio A
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Acyl Coenzyme A - metabolism Animals Biology Cellular signal transduction Coenzyme A Ligases - genetics Coenzyme A Ligases - metabolism Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Enzymes Fatty acid metabolism Fatty acids Fatty Acids - metabolism Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Gene Expression Regulation Genetic aspects HEK293 Cells Humans Hyperglycemia Insulin - genetics Insulin - metabolism Insulin resistance Ligases Lipid Metabolism Lipids Male Metabolism Mice Physiological aspects Proteins Signal Transduction Transcriptional Activation Triglycerides - metabolism
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