lin-28 controls the succession of cell fate choices via two distinct activities

lin-28 is a conserved regulator of cell fate succession in animals. In Caenorhabditis elegans, it is a component of the heterochronic gene pathway that governs larval developmental timing, while its vertebrate homologs promote pluripotency and control differentiation in diverse tissues. The RNA bind...

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Veröffentlicht in:	PLoS genetics 2012-03, Vol.8 (3), p.e1002588-e1002588
Hauptverfasser:	Vadla, Bhaskar, Kemper, Kevin, Alaimo, Jennifer, Heine, Christian, Moss, Eric G
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Animals Bacterial genetics Binding proteins Biology Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - growth & development Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Cell Differentiation - genetics DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Expression Regulation, Developmental Genes Genetic aspects Genetics Larva - genetics Larva - growth & development MicroRNAs Nematodes Nuclear Proteins - genetics Nuclear Proteins - metabolism Phenotype Physiological aspects Proteins Repressor Proteins - genetics RNA Transcription Factors - genetics Transcription Factors - metabolism
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