The meiotic recombination checkpoint suppresses NHK-1 kinase to prevent reorganisation of the oocyte nucleus in Drosophila

The meiotic recombination checkpoint is a signalling pathway that blocks meiotic progression when the repair of DNA breaks formed during recombination is delayed. In comparison to the signalling pathway itself, however, the molecular targets of the checkpoint that control meiotic progression are not...

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Veröffentlicht in:	PLoS genetics 2010-10, Vol.6 (10), p.e1001179-e1001179
Hauptverfasser:	Lancaster, Oscar M, Breuer, Manuel, Cullen, C Fiona, Ito, Takashi, Ohkura, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Biology/Cell Growth and Division Cell Biology/Developmental Molecular Mechanisms Cell Biology/Nuclear Structure and Function Cell division Cell Line Cell Nucleus - metabolism Cell Polarity DNA Breaks, Double-Stranded - radiation effects DNA Damage DNA repair DNA Repair - genetics Drosophila Drosophila melanogaster - cytology Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Female Genetics Genetics and Genomics/Chromosome Biology Genetics and Genomics/Nuclear Structure and Function Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Histones - metabolism Immunoblotting Kinases Male Meiosis - genetics Metazoa Models, Biological Molecular Biology/Histone Modification Molecular Biology/Recombination Mutation Oocytes - metabolism Phosphorylation Protamine Kinase - genetics Protamine Kinase - metabolism Proteins
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