Rewiring of PDZ domain-ligand interaction network contributed to eukaryotic evolution

PDZ domain-mediated interactions have greatly expanded during metazoan evolution, becoming important for controlling signal flow via the assembly of multiple signaling components. The evolutionary history of PDZ domain-mediated interactions has never been explored at the molecular level. It is of gr...

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Veröffentlicht in:	PLoS genetics 2012-02, Vol.8 (2), p.e1002510-e1002510
Hauptverfasser:	Kim, Jinho, Kim, Inhae, Yang, Jae-Seong, Shin, Young-Eun, Hwang, Jihye, Park, Solip, Choi, Yoon Sup, Kim, Sanguk
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding Sites Biological Evolution Biology Cellular signal transduction Databases, Protein Disease - genetics Evolution Evolution, Molecular Genetic aspects Humans Kinases Ligands Ligands (Biochemistry) Medical research Metazoa Molecular Sequence Data Mutation Nervous System - metabolism PDZ Domains Phosphorylation Physiological aspects Protein Binding Protein-protein interactions Proteins Structure-Activity Relationship Vertebrates - genetics
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