The secreted immunoglobulin domain proteins ZIG-5 and ZIG-8 cooperate with L1CAM/SAX-7 to maintain nervous system integrity

During nervous system development, neuronal cell bodies and their axodendritic projections are precisely positioned through transiently expressed patterning cues. We show here that two neuronally expressed, secreted immunoglobulin (Ig) domain-containing proteins, ZIG-5 and ZIG-8, have no detectable...

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Veröffentlicht in:	PLoS genetics 2012-07, Vol.8 (7), p.e1002819-e1002819
Hauptverfasser:	Bénard, Claire Y, Blanchette, Cassandra, Recio, Janine, Hobert, Oliver
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Animals Axons - metabolism Bacteria Biology Caenorhabditis elegans - genetics Caenorhabditis elegans - growth & development Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Cell Adhesion - genetics Cytogenetics Defects Experiments Gene expression Genetic aspects Genetics Health aspects Immunoglobulins Immunoglobulins - genetics Immunoglobulins - metabolism Medical research Nematodes Nerve Tissue Proteins - genetics Nervous system Nervous System - growth & development Nervous System - metabolism Neural Cell Adhesion Molecules - genetics Neural Cell Adhesion Molecules - metabolism Neurons Neurons - cytology Neurons - metabolism Physiological aspects Plasmids Protein Isoforms Protein Structure, Tertiary Proteins Systems development Zebrafish Proteins - genetics
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