Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2

Familial hemiplegic migraine type 2 (FHM2) is an autosomal dominant form of migraine with aura that is caused by mutations of the α2-subunit of the Na,K-ATPase, an isoform almost exclusively expressed in astrocytes in the adult brain. We generated the first FHM2 knock-in mouse model carrying the hum...

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Veröffentlicht in:	PLoS genetics 2011-06, Vol.7 (6), p.e1002129
Hauptverfasser:	Leo, Loredana, Gherardini, Lisa, Barone, Virginia, De Fusco, Maurizio, Pietrobon, Daniela, Pizzorusso, Tommaso, Casari, Giorgio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - metabolism Biology Cortical Spreading Depression - genetics Depression, Mental Disease Models, Animal Endoplasmic Reticulum - metabolism Female Females Gene Knock-In Techniques Genetic aspects Genetic susceptibility Glutamic Acid - metabolism HeLa Cells Humans Male Medicine Mice Mice, Transgenic Migraine Migraine with Aura - genetics Migraine with Aura - pathology Mutagenesis, Insertional Mutation Phenotype Propagation Protein Transport Reverse Transcriptase Polymerase Chain Reaction Risk factors Sodium-Potassium-Exchanging ATPase - genetics Sodium-Potassium-Exchanging ATPase - metabolism Statistical analysis Synaptic Transmission Transfection
Online-Zugang:	Volltext
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