Comparison of family history and SNPs for predicting risk of complex disease

The clinical utility of family history and genetic tests is generally well understood for simple Mendelian disorders and rare subforms of complex diseases that are directly attributable to highly penetrant genetic variants. However, little is presently known regarding the performance of these method...

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Veröffentlicht in:	PLoS genetics 2012-10, Vol.8 (10), p.e1002973-e1002973
Hauptverfasser:	Do, Chuong B, Hinds, David A, Francke, Uta, Eriksson, Nicholas
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology Cardiovascular disease Coronary vessels Family Family medical history Genetic polymorphisms Genetic Predisposition to Disease Genetic variation Health risk assessment Humans Liability Likelihood Functions Mathematics Methods Models, Genetic Multifactorial Inheritance Pedigree Polymorphism, Single Nucleotide Quantitative genetics Risk Risk assessment Risk factors ROC Curve Stock options
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