Transcriptional regulation of rod photoreceptor homeostasis revealed by in vivo NRL targetome analysis

A stringent control of homeostasis is critical for functional maintenance and survival of neurons. In the mammalian retina, the basic motif leucine zipper transcription factor NRL determines rod versus cone photoreceptor cell fate and activates the expression of many rod-specific genes. Here, we rep...

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Veröffentlicht in:	PLoS genetics 2012-04, Vol.8 (4), p.e1002649-e1002649
Hauptverfasser:	Hao, Hong, Kim, Douglas S, Klocke, Bernward, Johnson, Kory R, Cui, Kairong, Gotoh, Norimoto, Zang, Chongzhi, Gregorski, Janina, Gieser, Linn, Peng, Weiqun, Fann, Yang, Seifert, Martin, Zhao, Keji, Swaroop, Anand
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Basic-Leucine Zipper Transcription Factors - genetics Basic-Leucine Zipper Transcription Factors - metabolism Binding Sites Biology Disease Disease Models, Animal DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Eye Proteins - genetics Eye Proteins - metabolism Gene expression Gene Knockdown Techniques Gene Regulatory Networks Genetic aspects Genetic regulation Genetic transcription High-Throughput Nucleotide Sequencing Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Homeostasis Homeostasis - genetics Humans Jumonji Domain-Containing Histone Demethylases - genetics Jumonji Domain-Containing Histone Demethylases - metabolism Medicine Mice Mice, Inbred C57BL Neurons - metabolism Photoreceptors Physiological aspects Retina - metabolism Retina - physiology Retinal Dystrophies - genetics Retinal Dystrophies - metabolism Retinal Rod Photoreceptor Cells - metabolism Trans-Activators - genetics Trans-Activators - metabolism Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic
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