p63 and p73 transcriptionally regulate genes involved in DNA repair

The p53 family activates many of the same genes in response to DNA damage. Because p63 and p73 have structural differences from p53 and play distinct biological functions in development and metastasis, it is likely that they activate a unique transcriptional network. Therefore, we performed a genome...

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Veröffentlicht in:	PLoS genetics 2009-10, Vol.5 (10), p.e1000680-e1000680
Hauptverfasser:	Lin, Yu-Li, Sengupta, Shomit, Gurdziel, Katherine, Bell, George W, Jacks, Tyler, Flores, Elsa R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - metabolism Animals Apoptosis Binding sites BRCA2 Protein - metabolism Breast Neoplasms - genetics Breast Neoplasms - metabolism Cancer Cancer cells Cell Survival - genetics Cells, Cultured Chromatin Immunoprecipitation Cluster Analysis DNA Repair DNA Repair Enzymes - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Experiments Gene Expression Regulation Genes Genetic aspects Genetics and Genomics/Animal Genetics Genetics and Genomics/Bioinformatics Genetics and Genomics/Cancer Genetics Genomes Genotype & phenotype Health aspects Immunohistochemistry Leukemia Medical research Mice MRE11 Homologue Protein Nuclear Proteins - genetics Nuclear Proteins - metabolism Phosphoproteins - genetics Phosphoproteins - metabolism Physiological aspects Promoter Regions, Genetic Rad51 Recombinase - metabolism Radiation, Ionizing Rodents Trans-Activators - genetics Trans-Activators - metabolism Transcriptional Activation - genetics Tumor Protein p73 Tumor proteins Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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