Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains

In embryonic stem (ES) cells, bivalent chromatin domains with overlapping repressive (H3 lysine 27 tri-methylation) and activating (H3 lysine 4 tri-methylation) histone modifications mark the promoters of more than 2,000 genes. To gain insight into the structure and function of bivalent domains, we...

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Veröffentlicht in:	PLoS genetics 2008-10, Vol.4 (10), p.e1000242-e1000242
Hauptverfasser:	Ku, Manching, Koche, Richard P, Rheinbay, Esther, Mendenhall, Eric M, Endoh, Mitsuhiro, Mikkelsen, Tarjei S, Presser, Aviva, Nusbaum, Chad, Xie, Xiaohui, Chi, Andrew S, Adli, Mazhar, Kasif, Simon, Ptaszek, Leon M, Cowan, Chad A, Lander, Eric S, Koseki, Haruhiko, Bernstein, Bradley E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromatin Chromatin - chemistry Chromatin - metabolism Chromatin Immunoprecipitation Chromosome Mapping Computational Biology CpG Islands Developmental Biology/Developmental Molecular Mechanisms Developmental Biology/Stem Cells Embryonic Stem Cells - metabolism Epigenesis, Genetic Epigenetics Gene expression Genetics Genetics and Genomics/Bioinformatics Genetics and Genomics/Epigenetics Genetics and Genomics/Functional Genomics Genetics and Genomics/Genomics Genome Genome, Human Genomes Genomics Histones - metabolism Humans Islands Jumonji Domain-Containing Histone Demethylases Methylation Mice Molecular Biology/Histone Modification Molecular weight Oxidoreductases, N-Demethylating - metabolism Pluripotent Stem Cells - metabolism Polycomb-Group Proteins Promoter Regions, Genetic Protein Structure, Tertiary Proteins Repressor Proteins - genetics Repressor Proteins - metabolism RNA polymerase Studies
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