Global analysis of the impact of environmental perturbation on cis-regulation of gene expression

Genetic variants altering cis-regulation of normal gene expression (cis-eQTLs) have been extensively mapped in human cells and tissues, but the extent by which controlled, environmental perturbation influences cis-eQTLs is unclear. We carried out large-scale induction experiments using primary human...

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Veröffentlicht in:	PLoS genetics 2011-01, Vol.7 (1), p.e1001279
Hauptverfasser:	Grundberg, Elin, Adoue, Veronique, Kwan, Tony, Ge, Bing, Duan, Qing Ling, Lam, Kevin C L, Koka, Vonda, Kindmark, Andreas, Weiss, Scott T, Tantisira, Kelan, Mallmin, Hans, Raby, Benjamin A, Nilsson, Olle, Pastinen, Tomi
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone Morphogenetic Protein 2 - pharmacology Cell Biology/Gene Expression Dexamethasone - pharmacology Dinoprostone - pharmacology Environmental Exposure Experiments Female Gene expression Gene Expression Profiling Gene Expression Regulation - drug effects Gene Regulatory Networks Genetic aspects Genetic Markers Genetics Genetics and Genomics/Complex Traits Genetics and Genomics/Disease Models Genetics and Genomics/Functional Genomics Genetics and Genomics/Gene Expression Genetics and Genomics/Pharmacogenomics Genomes Genotype Humans Male Medical research MEDICIN MEDICINE Organ Specificity - genetics Osteoblasts Osteoblasts - drug effects Osteoblasts - metabolism Polymorphism, Single Nucleotide - genetics Population Proteins Quantitative Trait Loci Regulatory Sequences, Nucleic Acid - drug effects Regulatory Sequences, Nucleic Acid - genetics
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