Variation in MSRA modifies risk of neonatal intestinal obstruction in cystic fibrosis

Meconium ileus (MI), a life-threatening intestinal obstruction due to meconium with abnormal protein content, occurs in approximately 15 percent of neonates with cystic fibrosis (CF). Analysis of twins with CF demonstrates that MI is a highly heritable trait, indicating that genetic modifiers are la...

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Veröffentlicht in:	PLoS genetics 2012-03, Vol.8 (3), p.e1002580-e1002580
Hauptverfasser:	Henderson, Lindsay B, Doshi, Vishal K, Blackman, Scott M, Naughton, Kathleen M, Pace, Rhonda G, Moskovitz, Jackob, Knowles, Michael R, Durie, Peter R, Drumm, Mitchell L, Cutting, Garry R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology Cystic fibrosis Cystic Fibrosis - complications Cystic Fibrosis - genetics Cystic Fibrosis - metabolism Cystic Fibrosis Transmembrane Conductance Regulator - genetics Cystic Fibrosis Transmembrane Conductance Regulator - metabolism Development and progression Fetal diseases Genes Genetic aspects Genetic Association Studies Genetic variation Genetics Goblet Cells - pathology Haplotypes Humans Intestinal Obstruction - complications Intestinal Obstruction - genetics Intestinal Obstruction - metabolism Methionine Sulfoxide Reductases - genetics Methionine Sulfoxide Reductases - metabolism Mice Mice, Inbred CFTR Mutation Physiological aspects Polymorphism, Single Nucleotide
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