GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline

Nuage are amorphous ultrastructural granules in the cytoplasm of male germ cells as divergent as Drosophila, Xenopus, and Homo sapiens. Most nuage are cytoplasmic ribonucleoprotein structures implicated in diverse RNA metabolism including the regulation of PIWI-interacting RNA (piRNA) synthesis by t...

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Veröffentlicht in:	PLoS genetics 2009-09, Vol.5 (9), p.e1000635-e1000635
Hauptverfasser:	Ma, Lang, Buchold, Gregory M, Greenbaum, Michael P, Roy, Angshumoy, Burns, Kathleen H, Zhu, Huifeng, Han, Derek Y, Harris, R Alan, Coarfa, Cristian, Gunaratne, Preethi H, Yan, Wei, Matzuk, Martin M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Argonaute Proteins Cell Biology/Developmental Molecular Mechanisms Cement Developmental Biology/Developmental Molecular Mechanisms Developmental Biology/Germ Cells DNA damage DNA methylation Down-Regulation Drosophila Proteins - genetics Drosophila Proteins - metabolism Epigenetics Female Genetics and Genomics/Animal Genetics Genetics and Genomics/Epigenetics Infertility Infertility, Male - genetics Infertility, Male - metabolism Male Meiosis Mice Mice, Inbred C57BL Mice, Knockout Microscopy Molecular Biology/RNA-Protein Interactions Physiological aspects Proteins Proteins - genetics Proteins - metabolism Retroelements Retrotransposons RNA RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Spermatozoa - cytology Spermatozoa - metabolism Studies
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