Oncogenic pathway combinations predict clinical prognosis in gastric cancer

Many solid cancers are known to exhibit a high degree of heterogeneity in their deregulation of different oncogenic pathways. We sought to identify major oncogenic pathways in gastric cancer (GC) with significant relationships to patient survival. Using gene expression signatures, we devised an in s...

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Veröffentlicht in:	PLoS genetics 2009-10, Vol.5 (10), p.e1000676-e1000676
Hauptverfasser:	Ooi, Chia Huey, Ivanova, Tatiana, Wu, Jeanie, Lee, Minghui, Tan, Iain Beehuat, Tao, Jiong, Ward, Lindsay, Koo, Jun Hao, Gopalakrishnan, Veena, Zhu, Yansong, Cheng, Lai Ling, Lee, Julian, Rha, Sun Young, Chung, Hyun Cheol, Ganesan, Kumaresan, So, Jimmy, Soo, Khee Chee, Lim, Dennis, Chan, Weng Hoong, Wong, Wai Keong, Bowtell, David, Yeoh, Khay Guan, Grabsch, Heike, Boussioutas, Alex, Tan, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Care and treatment Cell Line, Tumor Classification Cohort Studies Computational Biology/Genomics Deregulation Female Gastroenterology and Hepatology/Gastrointestinal Cancers Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Genetics and Genomics/Gene Expression Humans Male Middle Aged Mortality Multivariate analysis Patients Prognosis Risk factors Signal Transduction Singapore Stomach cancer Stomach Neoplasms - diagnosis Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Tumors Young Adult
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