E1 ubiquitin-activating enzyme UBA-1 plays multiple roles throughout C. elegans development

Poly-ubiquitination of target proteins typically marks them for destruction via the proteasome and provides an essential mechanism for the dynamic control of protein levels. The E1 ubiquitin-activating enzyme lies at the apex of the ubiquitination cascade, and its activity is necessary for all subse...

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Veröffentlicht in:	PLoS genetics 2008-07, Vol.4 (7), p.e1000131-e1000131
Hauptverfasser:	Kulkarni, Madhura, Smith, Harold E
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Anaphase-Promoting Complex-Cyclosome Animals Caenorhabditis elegans Caenorhabditis elegans - embryology Caenorhabditis elegans - enzymology Caenorhabditis elegans - growth & development Caenorhabditis elegans Proteins - metabolism Developmental Biology Developmental Biology/Germ Cells Embryo, Nonmammalian Enzymes Fluorescent Dyes - metabolism Genes Genes, Helminth Genetic Complementation Test Genetics Genetics and Genomics/Gene Function Heterozygote Homozygote Hydrolysis Indoles - metabolism Male Meiosis Metazoa Mutation Nematoda Proteins Spermatozoa - abnormalities Spermatozoa - cytology Spermatozoa - metabolism Ubiquitin-Activating Enzymes - genetics Ubiquitin-Activating Enzymes - metabolism Ubiquitin-Protein Ligase Complexes - genetics Ubiquitin-Protein Ligase Complexes - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination Ubiquitins - genetics Ubiquitins - metabolism
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