Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation

A remarkable characteristic of the human major histocompatibility complex (MHC) is its extreme genetic diversity, which is maintained by balancing selection. In fact, the MHC complex remains one of the best-known examples of natural selection in humans, with well-established genetic signatures and b...

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Veröffentlicht in:	PLoS genetics 2010-10, Vol.6 (10), p.e1001157-e1001157
Hauptverfasser:	Andrés, Aida M, Dennis, Megan Y, Kretzschmar, Warren W, Cannons, Jennifer L, Lee-Lin, Shih-Queen, Hurle, Belen, Schwartzberg, Pamela L, Williamson, Scott H, Bustamante, Carlos D, Nielsen, Rasmus, Clark, Andrew G, Green, Eric D
Format:	Artikel
Sprache:	eng
Schlagworte:	African Continental Ancestry Group - genetics Aminopeptidases - genetics Aminopeptidases - immunology Antigen Presentation Asian Continental Ancestry Group - genetics European Continental Ancestry Group - genetics Evolutionary Biology/Human Evolution Experiments Gene Frequency Genes Genetic diversity Genetics and Genomics/Bioinformatics Genetics and Genomics/Genetics of the Immune System Genetics and Genomics/Population Genetics Genetics, Population Genomes Genotype Haplotypes Haplotypes - genetics Histocompatibility Antigens Class I - immunology Humans Immune system Immunology/Antigen Processing and Recognition Immunology/Autoimmunity Indians, North American - genetics Minor Histocompatibility Antigens Molecular Biology/RNA Splicing Phylogeny Polymorphism Polymorphism, Single Nucleotide Protein Biosynthesis RNA Processing, Post-Transcriptional RNA Splicing Selection, Genetic
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