Differing requirements for RAD51 and DMC1 in meiotic pairing of centromeres and chromosome arms in Arabidopsis thaliana
During meiosis homologous chromosomes pair, recombine, and synapse, thus ensuring accurate chromosome segregation and the halving of ploidy necessary for gametogenesis. The processes permitting a chromosome to pair only with its homologue are not fully understood, but successful pairing of homologou...
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| creator | Da Ines, Olivier Abe, Kiyomi Goubely, Chantal Gallego, Maria Eugenia White, Charles I |
| description | During meiosis homologous chromosomes pair, recombine, and synapse, thus ensuring accurate chromosome segregation and the halving of ploidy necessary for gametogenesis. The processes permitting a chromosome to pair only with its homologue are not fully understood, but successful pairing of homologous chromosomes is tightly linked to recombination. In Arabidopsis thaliana, meiotic prophase of rad51, xrcc3, and rad51C mutants appears normal up to the zygotene/pachytene stage, after which the genome fragments, leading to sterility. To better understand the relationship between recombination and chromosome pairing, we have analysed meiotic chromosome pairing in these and in dmc1 mutant lines. Our data show a differing requirement for these proteins in pairing of centromeric regions and chromosome arms. No homologous pairing of mid-arm or distal regions was observed in rad51, xrcc3, and rad51C mutants. However, homologous centromeres do pair in these mutants and we show that this does depend upon recombination, principally on DMC1. This centromere pairing extends well beyond the heterochromatic centromere region and, surprisingly, does not require XRCC3 and RAD51C. In addition to clarifying and bringing the roles of centromeres in meiotic synapsis to the fore, this analysis thus separates the roles in meiotic synapsis of DMC1 and RAD51 and the meiotic RAD51 paralogs, XRCC3 and RAD51C, with respect to different chromosome domains. |
| doi_str_mv | 10.1371/journal.pgen.1002636 |
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The processes permitting a chromosome to pair only with its homologue are not fully understood, but successful pairing of homologous chromosomes is tightly linked to recombination. In Arabidopsis thaliana, meiotic prophase of rad51, xrcc3, and rad51C mutants appears normal up to the zygotene/pachytene stage, after which the genome fragments, leading to sterility. To better understand the relationship between recombination and chromosome pairing, we have analysed meiotic chromosome pairing in these and in dmc1 mutant lines. Our data show a differing requirement for these proteins in pairing of centromeric regions and chromosome arms. No homologous pairing of mid-arm or distal regions was observed in rad51, xrcc3, and rad51C mutants. However, homologous centromeres do pair in these mutants and we show that this does depend upon recombination, principally on DMC1. This centromere pairing extends well beyond the heterochromatic centromere region and, surprisingly, does not require XRCC3 and RAD51C. In addition to clarifying and bringing the roles of centromeres in meiotic synapsis to the fore, this analysis thus separates the roles in meiotic synapsis of DMC1 and RAD51 and the meiotic RAD51 paralogs, XRCC3 and RAD51C, with respect to different chromosome domains.</description><identifier>ISSN: 1553-7404</identifier><identifier>ISSN: 1553-7390</identifier><identifier>EISSN: 1553-7404</identifier><identifier>DOI: 10.1371/journal.pgen.1002636</identifier><identifier>PMID: 22532804</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Arabidopsis - genetics ; Arabidopsis Proteins - genetics ; Arabidopsis thaliana ; Biology ; Cell Cycle Proteins - genetics ; Cell division ; Centromere - genetics ; Chromosome Pairing - genetics ; Chromosome Segregation ; Chromosomes ; Chromosomes - genetics ; DNA Fragmentation ; Euchromatin - genetics ; Genes ; Genetic aspects ; Genetics ; Genomics ; Heterochromatin ; Life Sciences ; Meiosis - genetics ; Mutant Proteins - genetics ; Physiological aspects ; Plant genetics ; Plant Infertility ; Proteins ; Rad51 Recombinase - genetics ; Rec A Recombinases - genetics ; Recombination, Genetic - genetics</subject><ispartof>PLoS genetics, 2012-04, Vol.8 (4), p.e1002636-e1002636</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Da Ines et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Da Ines O, Abe K, Goubely C, Gallego ME, White CI (2012) Differing Requirements for RAD51 and DMC1 in Meiotic Pairing of Centromeres and Chromosome Arms in Arabidopsis thaliana. 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The processes permitting a chromosome to pair only with its homologue are not fully understood, but successful pairing of homologous chromosomes is tightly linked to recombination. In Arabidopsis thaliana, meiotic prophase of rad51, xrcc3, and rad51C mutants appears normal up to the zygotene/pachytene stage, after which the genome fragments, leading to sterility. To better understand the relationship between recombination and chromosome pairing, we have analysed meiotic chromosome pairing in these and in dmc1 mutant lines. Our data show a differing requirement for these proteins in pairing of centromeric regions and chromosome arms. No homologous pairing of mid-arm or distal regions was observed in rad51, xrcc3, and rad51C mutants. However, homologous centromeres do pair in these mutants and we show that this does depend upon recombination, principally on DMC1. 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Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Da Ines, Olivier</au><au>Abe, Kiyomi</au><au>Goubely, Chantal</au><au>Gallego, Maria Eugenia</au><au>White, Charles I</au><au>Pawlowski, Wojciech P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differing requirements for RAD51 and DMC1 in meiotic pairing of centromeres and chromosome arms in Arabidopsis thaliana</atitle><jtitle>PLoS genetics</jtitle><addtitle>PLoS Genet</addtitle><date>2012-04-01</date><risdate>2012</risdate><volume>8</volume><issue>4</issue><spage>e1002636</spage><epage>e1002636</epage><pages>e1002636-e1002636</pages><issn>1553-7404</issn><issn>1553-7390</issn><eissn>1553-7404</eissn><abstract>During meiosis homologous chromosomes pair, recombine, and synapse, thus ensuring accurate chromosome segregation and the halving of ploidy necessary for gametogenesis. The processes permitting a chromosome to pair only with its homologue are not fully understood, but successful pairing of homologous chromosomes is tightly linked to recombination. In Arabidopsis thaliana, meiotic prophase of rad51, xrcc3, and rad51C mutants appears normal up to the zygotene/pachytene stage, after which the genome fragments, leading to sterility. To better understand the relationship between recombination and chromosome pairing, we have analysed meiotic chromosome pairing in these and in dmc1 mutant lines. Our data show a differing requirement for these proteins in pairing of centromeric regions and chromosome arms. No homologous pairing of mid-arm or distal regions was observed in rad51, xrcc3, and rad51C mutants. However, homologous centromeres do pair in these mutants and we show that this does depend upon recombination, principally on DMC1. This centromere pairing extends well beyond the heterochromatic centromere region and, surprisingly, does not require XRCC3 and RAD51C. In addition to clarifying and bringing the roles of centromeres in meiotic synapsis to the fore, this analysis thus separates the roles in meiotic synapsis of DMC1 and RAD51 and the meiotic RAD51 paralogs, XRCC3 and RAD51C, with respect to different chromosome domains.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22532804</pmid><doi>10.1371/journal.pgen.1002636</doi><orcidid>https://orcid.org/0000-0001-8152-5797</orcidid><orcidid>https://orcid.org/0000-0002-1868-3781</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Arabidopsis - genetics Arabidopsis Proteins - genetics Arabidopsis thaliana Biology Cell Cycle Proteins - genetics Cell division Centromere - genetics Chromosome Pairing - genetics Chromosome Segregation Chromosomes Chromosomes - genetics DNA Fragmentation Euchromatin - genetics Genes Genetic aspects Genetics Genomics Heterochromatin Life Sciences Meiosis - genetics Mutant Proteins - genetics Physiological aspects Plant genetics Plant Infertility Proteins Rad51 Recombinase - genetics Rec A Recombinases - genetics Recombination, Genetic - genetics |
| title | Differing requirements for RAD51 and DMC1 in meiotic pairing of centromeres and chromosome arms in Arabidopsis thaliana |
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