RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition

Caenorhabditis elegans SKN-1 (ortholog of mammalian Nrf1/2/3) is critical for oxidative stress resistance and promotes longevity under reduced insulin/IGF-1-like signaling (IIS), dietary restriction (DR), and normal conditions. SKN-1 inducibly activates genes involved in detoxification, protein home...

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Veröffentlicht in:	PLoS genetics 2010-08, Vol.6 (8), p.e1001048
Hauptverfasser:	Wang, Jinling, Robida-Stubbs, Stacey, Tullet, Jennifer M A, Rual, Jean-François, Vidal, Marc, Blackwell, T Keith
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - physiology Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Cell Biology/Cellular Death and Stress Responses Cell Biology/Gene Expression Cloning Developmental Biology/Aging Diabetes DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Experiments Gene Expression Regulation Genetic aspects Genetics Genetics and Genomics/Gene Expression Genetics and Genomics/Gene Function Genomes Longevity Molecular Biology/Post-Translational Regulation of Gene Expression Molecular Biology/Transcription Initiation and Activation Molecular Biology/Translational Regulation Nematoda Oxidative stress Physiological aspects Protein Biosynthesis Protein synthesis Proteins RNA Interference Stress response Stress, Physiological Studies Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic Worms
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