A Myo6 mutation destroys coordination between the myosin heads, revealing new functions of myosin VI in the stereocilia of mammalian inner ear hair cells

Myosin VI, found in organisms from Caenorhabditis elegans to humans, is essential for auditory and vestibular function in mammals, since genetic mutations lead to hearing impairment and vestibular dysfunction in both humans and mice. Here, we show that a missense mutation in this molecular motor in...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PLoS genetics 2008-10, Vol.4 (10), p.e1000207-e1000207
Hauptverfasser:	Hertzano, Ronna, Shalit, Ella, Rzadzinska, Agnieszka K, Dror, Amiel A, Song, Lin, Ron, Uri, Tan, Joshua T, Shitrit, Alina Starovolsky, Fuchs, Helmut, Hasson, Tama, Ben-Tal, Nir, Sweeney, H Lee, de Angelis, Martin Hrabe, Steel, Karen P, Avraham, Karen B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Animals Caenorhabditis elegans Cell Biology/Cytoskeleton Cell Biology/Morphogenesis and Cell Biology Cell culture Cell Line Chromosome Mapping Computational Biology/Evolutionary Modeling Deafness - genetics Deafness - metabolism Female Genetics and Genomics Genetics and Genomics/Animal Genetics Genetics and Genomics/Bioinformatics Genetics and Genomics/Disease Models Genetics and Genomics/Gene Discovery Genetics and Genomics/Gene Function Genetics and Genomics/Genetics of Disease Hair Hair Cells, Auditory, Inner - chemistry Hair Cells, Auditory, Inner - metabolism Hearing loss Humans Male Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Knockout Models, Molecular Mutation Mutation, Missense Myosin Heavy Chains - chemistry Myosin Heavy Chains - genetics Myosin Heavy Chains - metabolism Neuroscience/Sensory Systems Otolaryngology Protein Structure, Tertiary Protein Transport Proteins RNA polymerase Transport Vesicles - chemistry Transport Vesicles - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!