Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits

Mitochondrial dysfunction has been observed in skeletal muscle of people with diabetes and insulin-resistant individuals. Furthermore, inherited mutations in mitochondrial DNA can cause a rare form of diabetes. However, it is unclear whether mitochondrial dysfunction is a primary cause of the common...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PLoS genetics 2010-08, Vol.6 (8), p.e1001058
Hauptverfasser:	Segrè, Ayellet V, Groop, Leif, Mootha, Vamsi K, Daly, Mark J, Altshuler, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Case-Control Studies Clinical Medicine Cohort Studies Computational Biology/Genomics Diabetes Diabetes and Endocrinology/Type 2 Diabetes Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Endocrinology and Diabetes Endokrinologi och diabetes Gene mutations Genes Genetic aspects Genetic Variation Genetics Genetics and Genomics/Complex Traits Genetics and Genomics/Genetics of Disease Genome-Wide Association Study Glucose - metabolism Insulin resistance Klinisk medicin Medical and Health Sciences Medicin och hälsovetenskap Mitochondrial DNA Mitochondrial Proteins - genetics Muscles Physiological aspects Polymorphism, Single Nucleotide Quantitative Trait, Heritable Studies Type 2 diabetes
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!