Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci

Epidemiology and candidate gene studies indicate a shared genetic basis for celiac disease (CD) and rheumatoid arthritis (RA), but the extent of this sharing has not been systematically explored. Previous studies demonstrate that 6 of the established non-HLA CD and RA risk loci (out of 26 loci for e...

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Veröffentlicht in:	PLoS genetics 2011-02, Vol.7 (2), p.e1002004-e1002004
Hauptverfasser:	Zhernakova, Alexandra, Stahl, Eli A, Trynka, Gosia, Raychaudhuri, Soumya, Festen, Eleanora A, Franke, Lude, Westra, Harm-Jan, Fehrmann, Rudolf S N, Kurreeman, Fina A S, Thomson, Brian, Gupta, Namrata, Romanos, Jihane, McManus, Ross, Ryan, Anthony W, Turner, Graham, Brouwer, Elisabeth, Posthumus, Marcel D, Remmers, Elaine F, Tucci, Francesca, Toes, Rene, Grandone, Elvira, Mazzilli, Maria Cristina, Rybak, Anna, Cukrowska, Bozena, Coenen, Marieke J H, Radstake, Timothy R D J, van Riel, Piet L C M, Li, Yonghong, de Bakker, Paul I W, Gregersen, Peter K, Worthington, Jane, Siminovitch, Katherine A, Klareskog, Lars, Huizinga, Tom W J, Wijmenga, Cisca, Plenge, Robert M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Autoimmune diseases Biology Careers Celiac disease Celiac Disease - genetics Celiac Disease - immunology Diet Epidemiology Gene loci Genetic aspects Genetic Loci Genetic susceptibility Genetics Genome-Wide Association Study Genomes Grants Health risk assessment Histocompatibility antigens Histocompatibility Antigens - genetics HLA histocompatibility antigens Identification and classification Lymphocyte Activation Medicine Meta-analysis Pathogenesis Polymorphism, Single Nucleotide Quantitative trait loci Rheumatoid arthritis Risk factors Selection, Genetic Skin diseases Studies T-Lymphocytes - immunology T-Lymphocytes - metabolism
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