Age-dependent brain gene expression and copy number anomalies in autism suggest distinct pathological processes at young versus mature ages

Autism is a highly heritable neurodevelopmental disorder, yet the genetic underpinnings of the disorder are largely unknown. Aberrant brain overgrowth is a well-replicated observation in the autism literature; but association, linkage, and expression studies have not identified genetic factors that...

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Veröffentlicht in:	PLoS genetics 2012-03, Vol.8 (3), p.e1002592
Hauptverfasser:	Chow, Maggie L, Pramparo, Tiziano, Winn, Mary E, Barnes, Cynthia Carter, Li, Hai-Ri, Weiss, Lauren, Fan, Jian-Bing, Murray, Sarah, April, Craig, Belinson, Haim, Fu, Xiang-Dong, Wynshaw-Boris, Anthony, Schork, Nicholas J, Courchesne, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Factors Autism Autistic Disorder - genetics Autistic Disorder - metabolism Autistic Disorder - pathology Autopsy Biology Brain Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Differentiation - genetics Child Child, Preschool Development and progression DNA Copy Number Variations - genetics Female Gene Deletion Gene expression Gene Expression Regulation Gene Regulatory Networks Genetic aspects Genome, Human Genomics Health aspects Humans Male Medical research Medicine Middle Aged Neurons - metabolism Neurons - pathology Physiological aspects Physiology, Pathological Prefrontal Cortex - growth & development Prefrontal Cortex - metabolism Prefrontal Cortex - pathology Signal Transduction - genetics Studies
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