C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress

FoxO transcription factors and sirtuin family deacetylases regulate diverse biological processes, including stress responses and longevity. Here we show that the Caenorhabditis elegans sirtuin SIR-2.4--homolog of mammalian SIRT6 and SIRT7 proteins--promotes DAF-16-dependent transcription and stress-...

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Veröffentlicht in:	PLoS genetics 2012-09, Vol.8 (9), p.e1002948-e1002948
Hauptverfasser:	Chiang, Wei-Chung, Tishkoff, Daniel X, Yang, Bo, Wilson-Grady, Joshua, Yu, Xiaokun, Mazer, Travis, Eckersdorff, Mark, Gygi, Steven P, Lombard, David B, Hsu, Ao-Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Apoptosis Biology Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - physiology Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Caenorhabditis elegans Proteins - physiology Cell Nucleus - genetics Cell Nucleus - metabolism Colleges & universities DNA repair Experiments Forkhead Transcription Factors Genetic aspects Genetics Health aspects Heat-Shock Response - genetics Heat-Shock Response - physiology Histone Acetyltransferases - metabolism Kinases Longevity - genetics Longevity - physiology Microbial genetics Oxidative Stress - genetics Oxidative Stress - physiology Peptides Phosphorylation Physiological aspects Proteins Signal Transduction Sirtuins - genetics Sirtuins - metabolism Statistical analysis Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Transcription Factors - physiology
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