Investigation and functional characterization of rare genetic variants in the adipose triglyceride lipase in a large healthy working population

Recent studies demonstrated a strong influence of rare genetic variants on several lipid-related traits. However, their impact on free fatty acid (FFA) plasma concentrations, as well as the role of rare variants in a general population, has not yet been thoroughly addressed. The adipose triglyceride...

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Veröffentlicht in:	PLoS genetics 2010-12, Vol.6 (12), p.e1001239-e1001239
Hauptverfasser:	Coassin, Stefan, Schweiger, Martina, Kloss-Brandstätter, Anita, Lamina, Claudia, Haun, Margot, Erhart, Gertraud, Paulweber, Bernhard, Rahman, Yusof, Olpin, Simon, Wolinski, Heimo, Cornaciu, Irina, Zechner, Rudolf, Zimmermann, Robert, Kronenberg, Florian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Austria Chemical properties European Continental Ancestry Group - genetics Fatty acids Fatty Acids, Nonesterified - blood Female Gene mutations Genes Genetic aspects Genetic Variation Genetics Genetics and Genomics/Complex Traits Genetics and Genomics/Functional Genomics Genetics and Genomics/Gene Function Health aspects Health Status Humans Lipase Lipase - chemistry Lipase - genetics Lipase - metabolism Male Middle Aged Mutation Physiological aspects Polymorphism, Single Nucleotide Protein Structure, Tertiary Proteins
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